Volume 20, Issue 2 (Summer 2023)
Sci J Iran Blood Transfus Organ 2023, 20(2): 101-110 |
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Moghimi M, Mozafari S, Hashemi A, Saatchi M, Shamsi F, Zare H et al . Investigating the clinicopathological characteristics and survival of children with pancytopenia referred to Shahid Sadoughi Hospital during 2010-2015. Sci J Iran Blood Transfus Organ 2023; 20 (2) :101-110
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Investigating the clinicopathological characteristics and
survival of children with pancytopenia referred to Shahid Sadoughi Hospital during 2010-2015
Moghimi M.1, Mozafari S.2, Hashemi A.S.2, Saatchi M.3, Shamsi F.4, Zareh H.3, Moazen H.4
1Department of Pathology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
2Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
3Department of General Surgery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
4Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
Background and Objectives
Pancytopenia is one of the main characteristics of serious diseases among children. Therefore, identifying the initial signs of pancytopenia and finding the main cause of its occurrence is important for selection of the appropriate treatment strategy. This study was designed to investigate the clinicopathological and survival characteristics of children with pancytopenia referred to Shahid Sadoughi Hospital between 2010 and 2015.
Materials and Methods
In this retrospective study, 88 children aged 2 months to 16 years with pancytopenia symptoms were identified. The clinical, pathological, etiology, and survival characteristics of these children were examined and evaluated with the help of SPSS 25 software and log rank test were analyzed.
Results
The ratio of boys to girls was 1.1, which had no significant difference from each other. The frequency of pancytopenia among children one to six years old was equal to 48.87% (43 children) and more than other groups. Fever, bone pain, and general weakness were observed in 32 (36.36%), 17 (19.32%), and 16 (18.18%) children. Also, acute lymphoblastic leukemia and aplastic anemia were reported as the main causes of pancytopenia in 57 (59.1%) and 31 (31.8%) children. The results showed that 9 children had severe pancytopenia, and the survival rate in this group was lower than other children (p value <0.001).
Conclusions
Based on the results of this study, the possibility of pancytopenia in children aged 1-6 years with symptoms such as fever, bone pain, and general weakness should be considered to adopt the appropriate treatment and improve the survival rate.
Key words: Pancytopenia, Survival Rate, Pathology
Received: 27 Aug 2022
Accepted: 14 Jun 2023
Correspondence: Mozafari S., MSc of Clinical Biochemistry of Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services.
Postal code: 8915887857, Yazd, Iran. Tel: (+9835) 31834231; Fax: (+9835) 31834231
E-mail: sima.sam11@gmail.com
Full-Text: (1552 Views)
References:
- Zeb Jan A, Zahid B, Ahmad S, Gul Z. Pancytopenia in children: A 6-year spectrum of patients admitted to Pediatric Department of Rehman Medical Institute, Peshawar. Pak J Med Sci 2013; 29(5): 1153-7.
- Tareen SM, Tariq MM, Bajwa MA, Awan MA, Ahmad Z, Javed Y. Study of pancytopenia in Balochistan, Pakistan. Gomal J Med Sci 2012; 10(2): 248-51.
- Kuitunen T, Malmström J, Palva E, Pettersson T. Pancytopenia induced by low-dose methotrexate. A study of the cases reported to the Finnish Adverse Drug Reaction Register from 1991 to 1999. Scand J Rheumatol 2005; 34(3): 238-41.
- Jeurissen M, Boerbooms A, Van de Putte L. Pancytopenia related to azathioprine in rheumatoid arthritis. Ann Rheum Dis 1988; 47(6): 503-5.
- Chiravuri S, De Jesus O. Pancytopenia. StatPearls [Internet]. 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK563146/.
- Niemelä O, Parkkila S. Alcoholic macrocytosis–is there a role for acetaldehyde and adducts? Addict Biol 2004; 9(1): 3-10.
- Kumar R, Kalra S, Kumar H, Anand A, Madan H. Pancytopenia--a six year study. J Assoc Physicians India 2001; 49: 1078-81.
- Keyhanian S, Fotokian Z, Pourhabib A, Safaee Semnani N, Saravi A, Saravi S. Clinical and Hematological Findings in Patients with Pancytopenia. Journal of Mazandaran University of Medical Sciences 2016; 26(142): 249-53. [Article in Farsi]
- Nazi M, Raziq F. The incidence of underlying pathology in pancytopenia--An experience of 89 cases. J Postgrad Med Inst [Internet]. 2011 Sep. 27 [cited 2023 Jun. 21]; 18(1). Available from: https://jpmi.org.pk/index.php/jpmi/article/view/856
- Barik S, Chandoke RK, Verma AK. A prospective clinico-hematological study in 100 cases of pancytopenia in capital city of India. Journal of Applied Hematology 2014; 5(2): 45-50.
- Memon S, Shaikh S, Nizamani M. Etiological spectrum of pancytopenia based on bone marrow examination in children. J Coll Physicians Surg Pak 2008; 18(3): 163-7.
- Jain A, Naniwadekar M. An etiological reappraisal of pancytopenia-largest series reported to date from a single tertiary care teaching hospital. BMC Hematol 2013; 13(1): 10.
- Yadav BS, Varma A, Kiyawat P. Clinical profile of pancytopenia: a tertiary care experience. Int J Bioassays 2015; 4(01): 3673-7.
- Karwasra R, Singh S, Raza K, Sharma N, Varma S. A brief overview on current status of nanomedicines for treatment of pancytopenia: Focusing on chemotherapeutic regime. Journal of Drug Delivery Science and Technology 2021; 61: 102159.
- Abid FA. Pancytopenia among Children in Al-Semawa Teaching Hospital for Maternity and Childhood/Iraq. infection.1:2.
- Baig MA. Evaluation of bone marrow aspirate in paediatric patients with pancytopenia: a 2 years study. International Journal of Research in Medical Sciences 2017; 3(10): 2775-9.
- Dasgupta S, Mandal PK, Chakrabarti S. Etiology of Pancytopenia: An observation from a referral medical institution of Eastern Region of India. J Lab Physicians 2015; 7(02): 90-5.
- Gupta V, Tripathi S, Tilak V, Bhatia B. A study of clinico-haematological profiles of pancytopenia in children. Trop Doct 2008; 38(4): 241-3.
- Khan FS, Hasan RF. Bone marrow examination of pancytopenic children. J Pak Med Assoc 2012; 62(7): 660-3.
- Naseem S, Varma N, Das R, Ahluwalia J, Sachdeva MUS, Marwaha RK. Pediatric patients with bicytopenia/pancytopenia: review of etiologies and clinico-hematological profile at a tertiary center. Indian J Pathol Microbiol 2011; 54(1): 75-80.
- Pine M, Walter AW. Pancytopenia in hospitalized children: a five-year review. J Pediatr Hematol Oncol 2010; 32(5): e192-e4.
- Thappa SK, Masilamani D, Prasanna S, Krishnasamy A, Manjunathan R. Aetiological Profiles of Pancytopenia in Children between 2 months to 12 years of Age-A Retrospective Study from a Tertiary Care Centre, Chennai, India. Journal of Clinical & Diagnostic Research. 2022; 16(2): 33-6.
- Tufail A, Hashmi MA, Ahmad I, Butt MA. Clinico-etiological spectrum of Pancytopenia in children presenting in Allied Hospital, Faisalabad. Annals of Punjab Medical College (APMC) 2017; 11(2): 126-31.
- Das M, Saha A, Giri A. Clinico-aetiological and Demographic Profile of Pancytopenia among Children in a Tertiary Care Hospital of Northern Part of West Bengal-A Cross-sectional Study. Journal of Clinical & Diagnostic Research 2022; 16(3): 20-3.
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Sci J Iran Blood Transfus Organ 2023;20 (2): 101-110 |
|
Orginal Article
|
Investigating the clinicopathological characteristics and
survival of children with pancytopenia referred to Shahid Sadoughi Hospital during 2010-2015
Moghimi M.1, Mozafari S.2, Hashemi A.S.2, Saatchi M.3, Shamsi F.4, Zareh H.3, Moazen H.4
1Department of Pathology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
2Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
3Department of General Surgery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
4Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
Background and Objectives
Pancytopenia is one of the main characteristics of serious diseases among children. Therefore, identifying the initial signs of pancytopenia and finding the main cause of its occurrence is important for selection of the appropriate treatment strategy. This study was designed to investigate the clinicopathological and survival characteristics of children with pancytopenia referred to Shahid Sadoughi Hospital between 2010 and 2015.
Materials and Methods
In this retrospective study, 88 children aged 2 months to 16 years with pancytopenia symptoms were identified. The clinical, pathological, etiology, and survival characteristics of these children were examined and evaluated with the help of SPSS 25 software and log rank test were analyzed.
Results
The ratio of boys to girls was 1.1, which had no significant difference from each other. The frequency of pancytopenia among children one to six years old was equal to 48.87% (43 children) and more than other groups. Fever, bone pain, and general weakness were observed in 32 (36.36%), 17 (19.32%), and 16 (18.18%) children. Also, acute lymphoblastic leukemia and aplastic anemia were reported as the main causes of pancytopenia in 57 (59.1%) and 31 (31.8%) children. The results showed that 9 children had severe pancytopenia, and the survival rate in this group was lower than other children (p value <0.001).
Conclusions
Based on the results of this study, the possibility of pancytopenia in children aged 1-6 years with symptoms such as fever, bone pain, and general weakness should be considered to adopt the appropriate treatment and improve the survival rate.
Key words: Pancytopenia, Survival Rate, Pathology
Received: 27 Aug 2022
Accepted: 14 Jun 2023
Correspondence: Mozafari S., MSc of Clinical Biochemistry of Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services.
Postal code: 8915887857, Yazd, Iran. Tel: (+9835) 31834231; Fax: (+9835) 31834231
E-mail: sima.sam11@gmail.com
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