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:: Volume 18, Issue 2 (Summer 2021) ::
Sci J Iran Blood Transfus Organ 2021, 18(2): 105-116 Back to browse issues page
Frequency and factors associated with JAK2 V617F mutation in myeloproliferative neoplasms other than ABL-BCR disorders
E. Jafari , Sh. Dabiri, Gh. Tavasolian, M. Fekri Soofiabadi, B. Kalantari Khandani
Keywords: Mutation, Primary myelofibrosis, Neoplasms
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Type of Study: Research | Subject: Hematology
Published: 2021/07/1
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Sci J Iran Blood Transfus Organ 2021;18(2): 105-116
Original Article
 
 
 
 
 


Frequency and factors associated with JAK2 V617F
mutation in myeloproliferative neoplasms other than
ABL-BCR disorders
 
Jafari E.1, Dabiri Sh.1, Tavasolian Gh.2, Fekri Soofiabadi M.1, Kalantari Khandani B.2
 
1Pathology and Stem Cells Research Center, Kerman University of Medical Sciences, Kerman, Iran
2School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
 
 
Abstract
Background and Objectives
The association of JAK2 V617F mutation with myeloproliferative neoplasms was first reported in 2005. The present study was conducted to evaluate the frequency of JAK2 gene mutation in patients with myeloproliferative neoplasms in Kerman, Iran, from the years 2013 to 2018.
 
Materials and Methods
This descriptive cross-sectional study was performed among 276 patients with primary diagnosis of myeloproliferative neoplasms with subgroups PV, ET, PMF, and ABL-BCR negative referring to bone marrow laboratory of Bahonar Hospital during six years. Demographic, histopathologic, clinical, and JAK2 mutation data were collected. Data were analyzed by K2 test , Mann-Whitney U test and Kolmogorov–Smirnov test.
 
Results
Out of the total number of participants, 176 (64.9%) were male and 100 (35.1%) female with 101 (36.6%) patients having primary thrombocythemia, 81 (29.3%) primary myelofibrosis, 72 (26.1%) polycythemia vera, and 22 (8%) without diagnosis. Of all patients, JAK2 mutation was positive in 184 patients (66.6%). But the results showed that the frequency of positive mutations was 54.4% in primary thrombocytic patients, 59.2% in primary myelofibrosis patients, and 88.7% in polycythemia patients. This difference was statistically significant. ( p = 0.016)
 
Conclusions 
Considering the comparability of JAK2 V617F mutation rate in Iranian patients with myeloproliferative neoplasms and previous reports, in order to standardize the diagnosis and control of treatment and prognosis, it seems neccessary to evaluate this mutation along with other histopathologic evaluations.
 
Key words: Mutation, Primary myelofibrosis, Neoplasms
 
 
 
 
 
 
Received: 19 Sep  2020
Accepted:  1 May 2021
 
 

Correspondence: Jafari E., Pathologist and Surgeon. Associate Professor of Pathology and Stem Cells Research Center, Kerman University of Medical Sciences.
Postal code: 5636836335, Kerman, Iran. Tel: (+9834) 32235011; Fax: (+9834) 32227987
E-mail: ejfarda@yahoo.com
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Jafari E, Dabiri S, Tavasolian G, Fekri Soofiabadi M, Kalantari Khandani B. Frequency and factors associated with JAK2 V617F mutation in myeloproliferative neoplasms other than ABL-BCR disorders. Sci J Iran Blood Transfus Organ. 2021; 18 (2) :105-116
URL: http://bloodjournal.ir/article-1-1372-en.html


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Volume 18, Issue 2 (Summer 2021) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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