A case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K

Niazi, Vahid; Shahbazi, Massoumeh; ,

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Sci J Iran Blood Transfus Organ 2020; 17(4): 315-321

Case report

A case report of temporary and acquired vitamin
K-dependent clotting factor deficiency without any response
to administrated vitamin K

Niazi V.¹, Shahbazi M.², Moghadasi S.³

¹School of Advanced Technologies, Shahid Beheshti University of Medical Sciences, Tehran, Iran
²Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
³School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran

Abstract
Background and Objectives
Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin. In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated.

Case
We present a rare case of 43 year woman with acquired vitamin K deficiency and severe menorrhagia without any gynecological problem. The level of all Vitamin-K dependent coagulation factors, Fctor II, Factor VII, Factor IX, and Factor X decreased. Furthermore, even after multiple administration of Vitamin K and its oral consumption, still the level of coagulation factors and menorrhagia did not ameliorate.

Conclusions
Acquired VKCFD is one of the rare situations that can be life-threatening.

Key words: Vitamin K, Menorrhagia, Clotting Factor

Received: 4 Mar 2020
Accepted: 30 Sep 2020

Correspondence: Niazi V., PhD Student of Applied Cell Sciences. School of Advanced Technologies, Shahid Beheshti University of Medical Sciences.
Postal code: 19857-17443, Tehran, Iran. Tel: (+9821) 22439847; Fax: (+9821) 22439847
E-mail: v_niazi@yahoo.com