Volume 17, Issue 2 (Summer 2020)                   Sci J Iran Blood Transfus Organ 2020, 17(2): 91-99 | Back to browse issues page

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Mohamadimaram M, Gharehbaghian A, Abdollahi A, Khansari M. The prevalence of undesired blood group antibodies in thalassemia patients. Sci J Iran Blood Transfus Organ 2020; 17 (2) :91-99
URL: http://bloodjournal.ir/article-1-1335-en.html
The prevalence of undesired blood group antibodies in thalassemia patients
M.R. Mohamadimaram * , A. Gharehbaghian , A.R. Abdollahi , M. Khansari
Keywords: Blood Group Incompatibility, Thalassemia, Alloantibodies, Transfusion Reactions
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Sci J Iran Blood Transfus Organ 2020;17(2): 91-99
Original Article
 

 

The prevalence of undesired blood group antibodies in thalassemia patients
 
Mohammadimaram M.R.1, Gharehbaghian A.1,2, Abdollahi A.R.3, Khansari M.4
 
 
1School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
 
Abstract
Background and Objectives
Blood transfusion related alloimmunization is common among patients receiving regular blood transfusion, especially thalassemia patients. In this study we aimed to find the prevalence of alloimmunization among patients of thalassemia.
 
Materials and Methods
In this desciptional study, we screened 305 thalassemia patients (53.8% female and  46.2% male, age 4-38) referring to Imam Khomeini Hospital during 2017-2018 for presence of antibodies against blood group antigens. Then for those patients of positive antibody screening result we identified the antibody in each patient.
 
Results
Seven out of 305 patients in this study had positive antibody screening results. The most prevalent alloantibodies were detected to be anti-K (6 patients, 85.7%) and anti-E (2 patients, 28.57%). Also, 2 out of 7 patients with positive antibody results presented dual antibody of anti-K and anti-E.
 
Conclusions 
According to the results, anti-K and anti-E are the most likely antibodies presenting in patients of thalassemia with positive antibody screening results. This point is important to bear in mind in providing special blood supplies for thalassemics who are in need of regular blood transfusion. Prior to treatment of multitransfused patients like thalassemia the phenotyping of patients for important blood groups of Kell and Rh should be considered.
 
Key words: Blood Group Incompatibility, Thalassemia, Alloantibodies, Transfusion Reactions
 
 
 
 
 
 
 
Received:    1 Mar 2020
Accepted: 18 May 2020
 
 
 
 

Correspondence: Mohammadimaram M.R., MSc of Hematology and Blood Banking. School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences.
Postal Code: 8491754683, Tehran, Iran. Tel: (+9831) 52642041; Fax : (+9831) 52642041
E-mail: Mohamadimaram1990@yahoo.com
Type of Study: Research | Subject: Imunohematology
Published: 2020/06/30
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