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:: Volume 16, Issue 2 (Summer 2019) ::
Sci J Iran Blood Transfus Organ 2019, 16(2): 149-159 Back to browse issues page
A Review of Mitochondrial Biogenesis and Cellular Response
E. Noshadi , A. Arshi * , E. Mahmoudi , H. Jamshidian , M. Dehghani-Samani , R. Hashemzehi , M. Fadaei
Keywords: Key words: Mitochondria, Organelle Biogenesis, DNA
Full-Text [PDF 419 kb]   (7841 Downloads)     |   Abstract (HTML)  (4323 Views)
Type of Study: Review Article | Subject: Genetis
Published: 2019/07/15
Full-Text:   (19310 Views)
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Sci J Iran Blood Transfus Organ 2019; 16(2): 149-159
Review  Article
 

 

A Review of Mitochondrial Biogenesis and
Cellular Response
 
Noshadi E.1, Arshi A.2, Mahmoudi E.3, Jamshidian H.4,5, Dehghani-Samani M.6,
Hashemzehi R.1, Fadaei M.7
 
 
1Fars Science and Research Branch, Islamic Azad University, Shiraz, Iran
2Young Researchers and Elite Club, Najafabad Branch, Islamic Azad University, Najafabad, Iran
3Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
4Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
5Isfahan Blood Transfusion Center, Isfahan, Iran
6Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran
7Shahrekord University of Medical Science, Shahrekord, Iran
 
 
Abstract
Background and Objectives
Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover of this process. Mitochondrial malfunction or defects in any of the many pathways involved in mitochondrial biogenesis can lead to degenerative diseases and possibly play an important part in aging.
 
Materials and Methods
Because of the mitochondrial relationship with some factors such as matrix proteins, cell cycle and evolution, in this review article we examined the mitochondrial relationship with these factors and mechanisms. The data were extracted from NCBI and SID databases.
 
Results
Changes and mutations in mitochondria are common in most of the molecular processes and important diseases including cancer, but these mutations do not result in mitochondria deactivation. Investigating these pathways helps us to identify and treat diseases such as cancer.
 
Conclusions 
The mitochondria is the most important source of cellular energy supply, and mitochondrial damage can interfere with cellular activity and reduce the amount of energy produced and increase the production of free radicals. Mitochondria biogenesis is one of the protective methods of the cell against oxidative stress, which has a cell protective role.
 
Key words: Mitochondria, Organelle Biogenesis, DNA
 
 
 
Received:    6 Aug 2018
Accepted: 14 Nov 2018
 
 

Correspondence: Arshi A., MSc in Genetics. Young Researchers and Elite Club, Najafabad Branch, Islamic Azad  University.
 P.O.Box: 517, Najafabad, Iran. Tel: (+9831) 32607071; Fax: (+9831) 32607071
E-mail:
asghararshi@yahoo.com
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Noshadi E, Arshi A, Mahmoudi E, Jamshidian H, Dehghani-Samani M, Hashemzehi R et al . A Review of Mitochondrial Biogenesis and Cellular Response. Sci J Iran Blood Transfus Organ 2019; 16 (2) :149-159
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Volume 16, Issue 2 (Summer 2019) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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