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Prevalence of clinical and paraclinical features of leukemia among children with acute lymphoblastic leukemia in Sanandaj Besat Hospital, 2008- 2013
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B. Moradveisi   , P. Yazdanifard * , A. Fathollahpour |
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| Keywords: Key words: Leukemia, Hemoglobin, ALL (Acute lymphoblastic leukemia |
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Type of Study: Research |
Subject:
Pediatric Hematology and Oncology
Published: 2017/12/30
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Full-Text: (12445 Views) |
References:
- Kliegman RM, Stanton B, Geme JSt, Schor NF. Nelson Textbook of Pediatrics(Chapter 495). 20th ed. Philadelphia: Elsevier; 2016. p. 2437.
- Lanzkowsky Ph. Manual of Pediatric Hematology and Oncology. 5th ed. Philadelphia: Elsevier; 2010. p. 518-20.
- Farhangi H, Badiee Z, Bani-Hashem A. Evaluation of clinical symptoms and laboratory tests in patients with acute leukemia in Dr Sheikh Hematology-Oncology children’s hospital. Sixth meeting of 21-19 February 2010.
- Hashemi A, Manochehri Naieni MA, Eslami Z, Bahrami Ahmadi A, Kheirandish M, Rafieyan M. Evaluation of Prognostic and Predictive Factors in Pediatric Acute Lymphoblatic Leukemia Patients Admitted to Shahid Sadoughi Hospital. Journal of Shahid Sadoughi University of Medical Sciences 2009; 16(5): 14-9. [Article in Farsi]
- Matutes E, Brito-Babapulle V, Swansbury J, Ellis J, Morilla R, Dearden C, et al. Clinical and laboratory features of 78 cases of T-prolymphocytic leukemia. Blood 1991; 78(12): 3269-74.
- Momtazmanesh N, Vaziri S, Taghadosi M. Evaluation of characteristics of children with leukemia in Kashan area from 1994-99. Feyz 2000; 4(2): 103-9. [Article in Farsi]
- Alavi S, Arzanian MT, Moradmand M, Ashraftalesh H. Prevalence of Prognostic factors in children with acute lymphoblastic leukemia admitted to Mofid Children's Hospital from 1997-2000. Iran J Pediatr 2005; 15(3): 237-42. [Article in Farsi]
- Fragkandrea I, Nixon JA, Panagopoulou P. Signs and symptoms of childhood cancer: a guide for early recognition. Am Fam Physician 2013; 88(3): 185-92.
- Cheson BD, Cassileth PA, Head DR, Schiffer CA, Bennett JM, Bloomfield CD, et al. Report of the National Cancer Institute-sponsored workshop on
definitions of diagnosis and response in acute myeloid leukemia. J Clin Oncol 1990; 8(5): 813-9.
- Cheson BD, Bennett JM, Kopecky KJ, Büchner T, Willman CL, Estey EH, et al. Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. J Clin Oncol 2003; 21(24): 4642-9.
- Zombori L, Kovacs G, Csoka M, Derfalvi B. Symptoms in childhood leukaemia and lymphoma-a ten-year retrospective study. Pediatr Rheumatol Online J 2013; 11: 20.
- Jamshidi AA, Esmaielzadeh A, Kousha Ali. 8-year study of hematologic malignancies. J Zanjan Univ Med Sci 2004; 12(46): 47-53. [Article in Farsi]
- Hemmatyar M, Haji-Naghdi M. Comparison of clinical manifestations and age and sex distribution in childhood acute lymphoblastic leukemia and acute myelocytic leukemia. Med Sci J Islamic Azad Univ 2005; 15(3): 121-4. [Article in Farsi]
- Malcol SMA, Lym NNA. Childhood Cancer. In: Pizzo PA, Poplack DG. Principles and practice of pediatric oncology. 4th ed. Philadelphia: LWW Co; 2002. p. 556.
- Pui CH, Relling MV, Downing JR. Acute lymphoblastic leukemia. N Engl J Med 2004; 350(15): 1535-48.
- Pourreza A, Pedram M, Zandi Kh, Hashemi A. 5-year study of children with acute myeloid leukemia Healing Hospital. Journal of Kermanshah University of Medical Sciences(Behbood) 2006; 11(2): 41-3. [Article in Farsi]
- Hashemi AS, Ferdosian F, Bashardoust N, Saifuddin A. Effect of erythropoietin on anemia caused by acute lymphoblastic leukemia in children aged 1-15 [Thesis]. Yazd: Yazd Islamic Azad University; 2014. p. 10. [Persian]
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Sci J Iran Blood Transfus Organ 2018; 14(4): 281-288
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Prevalence of clinical and paraclinical features of leukemia
among children with acute lymphoblastic leukemia
in Sanandaj Besat Hospital, 2008- 2013
Moradveisi B.1, Yazdanifard P.1, Fathollahpour A.1
1Kurdistan University of Medical Sciences, Sanandaj, Iran
Abstract
Background and Objectives
One of the most common childhood malignancies is leukemia with prevalance of 40 per million among children aged under 15. This study aimed to determine the prevalence of clinical and paraclinical features of leukemia among children aged under 15 with acute lymphoblastic leukemia.
Materials and Methods
In this cross-sectional analysis of hospital records, clinical and paraclinical features of patients admitted to Besat Hospital during 2006-2012 were reviewed. Data were analyzed by Stata (version 11) software. c 2 test and t-test were used.
Results
Of the total study population (84 cases), 65.5% were male and 34.5% were female. The mean age was 6.13 ± 4/48 years. The most common clinical feauture was lethargy (78.6%) followed by history of fever (73.8%), pallor (34.5%), lymphadenopathy (29.8%), anemia (60.7%) and hepatosplenomegaly (48.8%). There was a significant correlation between T cell leukemia and lower hemoglobin level, and likewise with lower platelet count in children more than 8 years of age (p < 0.05).
Conclusions
This study revealed lethargy as the most common clinical feature in our study population. As well it showed a significant correlation between lower platelet count and age (above 8 years old); the same true between lower hemoglobin level and T cell leukemia.
Key words: Leukemia, Hemoglobin, ALL (Acute lymphoblastic leukemia)
Received: 27 Feb 2017
Accepted: 22 Oct 2017
Correspondence: Yazdanifard P., MD. Pediatric Resident, Kurdistan University of Medical Sciences.
Postal Code: 6617967617, Sanandaj, Iran. Tel: (+9887) 33235445; Fax: (+9887) 33232441
E-mail:
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parinyazdanifard@yahoo.com
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Moradveisi B, Yazdanifard P, Fathollahpour A. Prevalence of clinical and paraclinical features of leukemia among children with acute lymphoblastic leukemia in Sanandaj Besat Hospital, 2008- 2013. Sci J Iran Blood Transfus Organ 2017; 14 (4) :281-288 URL: http://bloodjournal.ir/article-1-1110-en.html
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