Volume 14, Issue 1 (Spring 2017)                   Sci J Iran Blood Transfus Organ 2017, 14(1): 1-7 | Back to browse issues page

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Pourfathollah A, Mogadam M, Goudarzi S. Increase in Natural auto antibodies against RBCs inhematologic disorders. Sci J Iran Blood Transfus Organ 2017; 14 (1) :1-7
URL: http://bloodjournal.ir/article-1-1033-en.html
Abstract:   (5402 Views)

Abstract

Background and Objectives

In recent years, Natural auto Abs (NAAbs) are considered as key factors in maintaining the immune homeostasis; NAAbs are also known as biomarkers in various diseases. This research, for the first time, was performed to identify NAAbs that are produced against RBCs following some physiologic changes in patients in comparison to healthy blood donors.    

Materials and Methods

In this fundamental-applied research, two groups of samples including 600 healthy blood donors and 324 patients who have shown pathologic disorders participated. All samples were screened for NAAbs but the identification panel was performed only in the case of positive reaction. Results were analyzed through  binominal test and by SPSS 16.  

Results

NAAbs were detected in 8.6% of healthy population and 17.9% of the patient population, all determined as positive reactions. Only two cases (1 anti-A1 and1 anti-P1) out of 30 were identifiable among the healthy group with auto antibody; however, in the patient group with auto antibody, 19 anti-IH cases, 1 anti-H cases, 2 anti-I cases, 2 anti-P1 cases, and 6 inconclusive cases were identified.

Conclusions

A significant difference between the frequency of NAAbs reactions against RBCs in the two groups was observed (p = 0.03). Furthermore,  anti-IH increases in hematologic diseases.

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Type of Study: Research | Subject: Imunohematology
Published: 2017/03/13

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