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:: Volume 20, Issue 2 (Summer 2023) ::
Sci J Iran Blood Transfus Organ 2023, 20(2): 143-154 Back to browse issues page
Reviewing the effect of exercise on hematopoietic stem cell mobilization
S. Hedayati , A.R. Rahimi , F. Aghaei , M. Mohsenzadeh
Keywords: Key words: Hematopoietic Stem Cell Transplantation, Exercise, G-CSF
Full-Text [PDF 549 kb]   (373 Downloads)     |   Abstract (HTML)  (523 Views)
Type of Study: Review Article | Subject: Hematology
Published: 2023/07/1
Full-Text:   (789 Views)
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Sci J Iran Blood Transfus Organ 2023;20 (2): 143-154
Review Article
 


Reviewing the effect of exercise on hematopoietic
stem cell mobilization

Hedayati S.1, Rahimi A.R.1, Aghaei F.1, Mohsenzadeh M.1


1Department of Exercise Physiology. Karaj Branch, Islamic Azad University, Karaj, Iran


Abstract
Background and Objectives
Hematopoietic stem cell transplantation (HSCT) is a promising treatment for the hematological disease. Although bone marrow is the major source of hematopoietic stem cells (HSCs), there is a small compartment of these cells in peripheral blood. Mobilization is the process of HSCs release into the peripheral blood, induced by several physiological and pharmaceutical factors. Granulocytecolony-stimulating factor (G-CSF) is the main exogenous drug for mobilization induction. The exercise is a non-invasive approach for mobilization stimulation. 

Materials and Methods
In this review, we searched the keywords of hematopoietic stem cell transplantation, mobilization, and exercise in reliable databases, including Google Scholar, PubMed, Scopus, and Elsevier. We selected the most relevant ones among potential candidates. Among the 98 selected articles, 63 articles met the necessary criteria and were evaluated.

Results
Exercise is safe and feasible in patients undergoing HSCT and can induce a 2-4 fold increase in peripheral blood HSC quantity. However, the influence is transient and drops back to baseline shortly after the exercise. Studies suggested that exercise-induced mobilization is intensity-dependent, and higher-intensity exercise induces mobilization more effectively than lower intensity.

Conclusions 
As the exercise’s effect is transient and insufficient compared to G-CSF, it cannot fully replace the exogenous G-CSF therapy in the clinic. However, it can be applied along with G-CSF as an adjuvant therapy to help with reducing apheresis time and duration, decreasing G-CSF dose and its related side effects, and preventing extra pharmaceutical interventions. 

Key words: Hematopoietic Stem Cell Transplantation, Exercise, G-CSF








Received: 7 Jan 2023
Accepted:1 Mar 2023



Correspondence: Rahimi A.R., PhD of Exercise Physiology. Karaj Branch, Islamic Azad University.
Postal code: 313-31483, Karaj, Iran. Tel: (+98261) 4418143-9; Fax: (+98261) 4418156
E-mail:
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Hedayati S, Rahimi A, Aghaei F, Mohsenzadeh M. Reviewing the effect of exercise on hematopoietic stem cell mobilization. Sci J Iran Blood Transfus Organ 2023; 20 (2) :143-154
URL: http://bloodjournal.ir/article-1-1479-en.html
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Volume 20, Issue 2 (Summer 2023) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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