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:: Volume 14, Number 2 (Summer 2017) ::
Sci J Iran Blood Transfus Organ 2017, 14(2): 118-125 Back to browse issues page
Frequency of Chromosome Disorders in the Childrenwith Acute Leukemia Referred to the OncSanandaj Besat Hospitalology Ward of
B. Moradveisi, H. Safari, D. Roshani, B. Khalafi, R. Raghizadeh Sarvestani
Abstract:   (420 Views)

Abstract

Background and Objectives

Blood Malignancies are the most frequent cancers in children including about 45% of diagnosed cancers in children. Chromosome disorders are found in most of patients with acute lymphoblastic leukemia. These disorders present valuable information for prognostic determinants.

Materials and Methods

This descriptive study includes all the children with acute leukemia having referred to the oncology ward of Besat Hospital of Sanandaj from 1385 to the end of the first half of 1394. Peripheral blood smear and bone marrow aspirations were taken from the children; RT-PCR method was used for determination of chromosome karyotypes so as to detect chromosome disorders. The data were analyzed by SPSS 11.5 & c2 test.

Results

Among 75 cases, 12 chromosome genotypes were observed. Normal chromosome genotype has the highest frequency with 41 cases (54.7%). t(12-21) chromosome disorder observed in 15 cases (20%) was the most frequent disorder. t(15-17) chromosome disorder observed in 5 cases (6.5%) was the next most frequent disorder. The only chromosome disorder observed in T lymphocyte leukemia was 47xy + 21 with the frequency of 1 case.

Conclusions

Based on the research findings, 54.7% of the children have no chromosome disorders. Different results are reported in different researches. Due to the importance of finding the types of chromosome translocation for prognostic determinants in children with leukemia, more research is required.

Keywords: Key words: Leukemia, Chromosome Disorders, Children
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Type of Study: Research | Subject: Hematology and Oncology
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Moradveisi B, Safari H, Roshani D, Khalafi B, Raghizadeh Sarvestani R. Frequency of Chromosome Disorders in the Childrenwith Acute Leukemia Referred to the OncSanandaj Besat Hospitalology Ward of . Sci J Iran Blood Transfus Organ. 2017; 14 (2) :118-125
URL: http://bloodjournal.ir/article-1-1055-en.html
Volume 14, Number 2 (Summer 2017) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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