[Home ] [Archive]   [ فارسی ]  
:: Main :: About us :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Subscription::
News& Events::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Indexing
                        
..
:: Volume 10, Issue 2 (Summer 2013) ::
Sci J Iran Blood Transfus Organ 2013, 10(2): 147-153 Back to browse issues page
The effect of silver nanoparticles on blood cells in male rats
S. Rezaei-Zarchi , M.H. Taghavi-Foumani , S.A. Razavi Sheshdeh , M. Negahdary
Abstract:   (10959 Views)

  Abstract

 Background and Objectives

 Nanotechnology is the production, use and development of tools and materials whose dimensions are about 1 to 100 nm. Silver nanoparticles are used in packaging, cosmetics, health, medical and poultry industries. Due to the excessive application of silver nanoparticles with its broad antibacterial properties, the evaluation of biocompatibility of silver nanoparticles on biological systems appears to be necessary. The aim of this study is to investigate the effects of nanosilver on blood cells in rats.

 

 Materials and Methods

 In this study, silver nanoparticles with doses of 25, 50, 100 and 200 mg/kg body weight orally administered for 28 days to 50 male rats were placed in five groups each of which with ten rats. Then, blood samples were taken from rats finally, blood cell count was determined and blood coagulation tests were performed.

 

 Results

 In this study, no significant changes on the number of blood cells including white blood cells, red blood cells, and platelets were observed in any of the doses used. Despite normal blood clotting time at all doses tested, bleeding time test and clot retraction test showed significant changes at high doses, i.e. 200 mg/kg body weight of rats.

  

 Conclusions

 The increased bleeding time and decreased percentage of the serum collected are the consequence of the suppressive effect of silver nanoparticles on the clotting function of platelets in high doses.

 

  

 

Keywords: Key words: Nanoparticles, Blood cells, Rats
Full-Text [PDF 319 kb]   (2895 Downloads)    
Type of Study: Research | Subject: Hematology
Published: 2013/08/24
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rezaei-Zarchi S, Taghavi-Foumani M, Razavi Sheshdeh S, Negahdary M. The effect of silver nanoparticles on blood cells in male rats. Sci J Iran Blood Transfus Organ 2013; 10 (2) :147-153
URL: http://bloodjournal.ir/article-1-770-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 2 (Summer 2013) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
Persian site map - English site map - Created in 0.07 seconds with 39 queries by YEKTAWEB 4645