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:: Volume 9, Issue 3 And بخش 1 (Autumn 2012) ::
Sci J Iran Blood Transfus Organ 2012, 9(3 And بخش 1): 273-280 Back to browse issues page
Association between the PAI-1 4G/5G promoter polymorphism and recurrent miscarriage
A. Khaleghparast , S. Morovvati Dr.
Abstract:   (13771 Views)

  Abstract

 Background and Objectives

  One of the factors known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is the 4G/5G polymorphisms in the promoter region of the ‍‍ plasminogen activator inhibitor-1(PAI-1). This study aimed to determine the association between RSA and this polymorphism in Iranian patients.

 

 Materials and Methods

 In this case-control study, 30 patients with the background of two or more consecutive unexplained abortions and 10 women with at least two live births without a miscarriage who referred to Baqiyatallah hospital and Avicenna Infertility Clinic were analyzed for the PAI-1 4G/5G promoter polymorphism by the PCR-RFLP method. Results achieved from estimating the genotype of this polymorphism were analyzed by the SPSS16 and Chi Square.

 

 Results

 4G allele frequency was 46.7 % in the patient group and 40% in the control group. Frequency of the PAI-1 4G/5G promoter polymorphism was 76.7% in patients and 80% in controls. For PAI-1 4G/5G promoter polymorphism, 60% of patients and 80% of controls were heterozygote. Furthermore, 16.7% of patients were homozygote, though there were not any homozygote in controls.

  

 Conclusions

 These findings failed to support the relationship between PAI-1 4G/5G promoter polymorphism and the increasing risk of RSA in evaluated Iranian women.

  

 

Keywords: Key words: Spontaneous Abortion, Thrombophilia, Polymorphism(Genetic), Plasminogen Activator Inhibitor 1
Full-Text [PDF 271 kb]   (6991 Downloads)    
Type of Study: Research | Subject: Genetis
Published: 2013/08/27
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Khaleghparast A, Morovvati S. Association between the PAI-1 4G/5G promoter polymorphism and recurrent miscarriage. Sci J Iran Blood Transfus Organ. 2012; 9 (3) :273-280
URL: http://bloodjournal.ir/article-1-681-en.html


Volume 9, Issue 3 And بخش 1 (Autumn 2012) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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