Cerebral venous thrombosis in a child with Acute Lymphoblastic Leukemia and G20210A mutation of prothrombine gene during treatment

 Eshghi P.¹, Amin Asnafi A.¹

  ¹ Shahid Beheshti University of Medical Sciences,Tehran,Iran

  Abstract

 Background and Objectives

 Cerebral vein thrombosis is a relatively rare but important complication during treatment of Acute Lymphoblastic Leukemia(ALL) in children.

 Case

 A 12 year old boy with pre-B ALL during the consolidation phase of treatment with BFM protocol was admitted with severe headache imaging study showed cerebral venous thrombosis in left sigmoid and lateral sinuses. Diagnostic evaluation revealed heterozygot mutation in G20210A prothombin gene.

 Conclusions

 Some hereditary hypercoagulability states such as prothrombin G20210A heterogeneity, play an important role in childhood thrombotic events during treatment of hematologic malignancy with medications such as L-asparginase. So venous thrombosis prophylaxis in this situation should be considered.

 Key words : Leukemia, Venous Thrombosis, Mutation, Prothrombin 

 Sci J Iran Blood Transfus Org 2011 8(2): 143-148