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:: Volume 8, Issue 2 (Summer 2011) ::
Sci J Iran Blood Transfus Organ 2011, 8(2): 115-121 Back to browse issues page
Characteristics of CoolClot, the invented novel hemostatic agent
S.M.J. Mortazavi Dr. * , M. Atefi , P. Roshan-shomal Dr., N. Tanide Dr., N. Raadpey , Z. Bagheri
Abstract:   (15096 Views)

  Abstract

 Background and Objectives

 Uncontrolled bleeding is the first leading cause of preventable death in the battlefield and the second cause of mortality in civil accidents. Incompressible hemorrhage control is among the interventions that drastically increase the survival rate of the wounded individuals.

 

 Materials and Methods

 Three healthy hybrid dogs were selected and after induction of anesthesia with Ether, either arterial puncture by a needle or arteriotomy was performed on both groin regions of the dogs . For control arteries, only a 4 min pressure using a sterile gauze was performed, while for the femoral arteries of the opposite side, Cool Clot hemostatic agent was topically used before the pressure. To assess the Coagulation Time (CT), blood samples were collected from 10 volunteer students. CT was measured by a chronometer according to standard Lee -White method.

 

 Results

 In dog animal model, the Bleeding Time (BT) in control arteries (no hemostatic agent) was more than 15 minutes, while in case of the opposite sides which were treated with Cool Clot hemostatic agent, the BT was only up to 5 minutes. In the human phase of the study, the mean coagulation time in control blood samples was 253.4 ± 4.1 sec, while for blood samples treated with bentonite, zeolite and Cool Clot the mean times were 149.5 ± 50.0 , 162.3 ± 74.5 and 143.4 ± 114.6 sec, respectively.

 

 Conclusions

 The results obtained in this study indicate the significant efficacy of Cool Clot in shortening the BT in dog model or CT in human blood samples.

 

Keywords: Hemorrhage, Hemostases, Bentonite, Zeolites
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Type of Study: Research | Subject: Hematology
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Mortazavi S, Atefi M, Roshan-shomal P, Tanide N, Raadpey N, Bagheri Z. Characteristics of CoolClot, the invented novel hemostatic agent . Sci J Iran Blood Transfus Organ. 2011; 8 (2) :115-121
URL: http://bloodjournal.ir/article-1-485-en.html


Volume 8, Issue 2 (Summer 2011) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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