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:: Volume 6, Issue 1 (Spring 2009) ::
Sci J Iran Blood Transfus Organ 2009, 6(1): 41-50 Back to browse issues page
Out-patient stem cell transplantation in patients with multiple myeloma in Shariati Hospital
M. Khani Dr. * , K. Alimoghadam Dr., A. Karimi Dr., A. Mousavi , A. Ghavamzadeh Dr.
Abstract:   (34841 Views)

  Abstract

 Background and Objectives

 Multiple myeloma (MM) is a clonal disorder of hematopoietic stem cell. We have been doing in-patient stem cell transplant (SCT) in Iran since 1991 however, this is the first time we have decided to embark on out-patient SCT.

 

 Materials and Methods

 In this cohort study, the selected Multiple Myeloma patients received outpatient stem cell transplantation. They were then discharged and followed by an out-patient SCT team including a general physician, a staff nurse and a care giver during the neutropenic period. All data were collected and analyzed using ANOVA test, Caplan mayer curve and SPSS 11.5.

 

 Results

 Forty four patients received in-patient or out-patient autologus SCT. The rates of median hospital stay were 28 (19-54) and 6.5 days (1-8) in in-patient and out-patient groups, respectively. Median home visit by team was 10.5 days. There were not significant differences (p<0.001) between these groups as far as apheresis days, granulocyte colony stimulatig factor (GCSF) dosage as mobilization, number of mono nuclear cell (MNC) or cluster of differentiation (CD)34+ cell parameters are concerned. There was also a significant decrease in total cost of SCT in out-patient group by 70% (p<0.017) including visit cost with 80% decrease (p<0.01), drug cost with 50% (p<0.004), laboratory cost with 70% (p<0.02), and hospital cost with 70% (p<0.04).

 

 Conclusions

 Our results show that out-patient autolgous SCT in multiple myeloma patients is feasible and its complications are manageable. Significant reduction in cost and bed requirement is also inevitable.

  

  Key words : Multiple Myeloma, Stem Cell Transplantation, Apheresis

Keywords: Multiple Myeloma, Stem Cell Transplantation, Apheresis
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Type of Study: Research | Subject: Stem cells
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Khani M, Alimoghadam K, Karimi A, Mousavi A, Ghavamzadeh A. Out-patient stem cell transplantation in patients with multiple myeloma in Shariati Hospital . Sci J Iran Blood Transfus Organ. 2009; 6 (1) :41-50
URL: http://bloodjournal.ir/article-1-301-en.html


Volume 6, Issue 1 (Spring 2009) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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