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Showing 2 results for Key Words: Myocardial Infarction

Dr. A.r. Farsinejad, Dr. B. Sarvar Azimzadeh, Sh. Kazemzadeh,
Volume 11, Issue 3 (9-2014)
Abstract

  Abstract

 Background and Objectives

 Arterial thrombosis, with MI as the severe complication, represents the most frequent cause of death in the world. Although there is no doubt that genetic factors contribute significantly to the prothrombotic state, the data on polymorphisms in candidate genes are still inconclusive. We investigated if T13254C polymorphism in the platelet GPVI gene confers an increased risk of premature acute myocardial infarction (MI).

 Materials and Methods

 We conducted a case-control study of 100 young males with premature acute MI and 100 inpatient controls of the similar age, without any known heart diseases. Genotyping was done using PCR-RFLP. The significance of differences between cases and controls with respect to the variables was tested using student’s t test and Chi square. Logical regression model was used to control confounding variables.

  

 Results

 The allele frequencies of T13254C polymorphism did not differ between patients (30%) and controls (33%), and this polymorphism was not associated with premature acute MI (p < 0.05). Logistic regression analysis also indicated no association between these polymorphisms and premature MI.

 Conclusions

 Compatible with our study, the T13254C polymorphism of platelet collagen receptor did not play a significant role in the development of premature MI.

  


M. Moradi, H. Alaoddolehei, M. Farajpour, F. Sadighian, Dr. M. Naghipour, Dr. Iraj Jafaripour,
Volume 15, Issue 2 (6-2018)
Abstract

Abstract
Background and Objectives
Myocardial infarction is one of the heart diseases that occurs due to prolonged ischemia of the heart muscle. The disease is associated with environmental and genetic factors. The association between ABO blood group antigens and some diseases has been proven. The aim was to investigate the relationship between ABO blood group antigens and antigen D from the Rh system with myocardial infarction.
 
Materials and Methods
This case-control study was performed on 281 patients with myocardial infarction and 398 people without the disease. Information on age and gender were recorded and determination of ABO/Rh blood grouping was performed by standard methods.
 
Results
The average age of patients was 66.5 ± 15.1 and that of the control group 54 ± 8.9. No significant difference in the distribution of ABO blood group system was found between patients and controls. But the number of negative Rh was significantly higher in patients than controls (p = 0.01).
 
Conclusions 
Due to the lack of significant association between ABO system versus significant association of Rh system with myocardial infarction in this study and given the findings of the other studies with no substantial evidence, further studies including more samples and other antigens of Rh system are recommended.
 


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