Dr. M. Samadi, Dr. A.h. Ghasemzade, Gh. Sarizade, Dr. S. Ebrahimi, Sh. Saati, A. Abassinejad-Pour, Dr. L. Nazar Ardekani,
Volume 10, Issue 4 (winter 2014)
Abstract
Abstract
Background and Objectives
Selection of healthy blood donors is an important process to identify high risk volunteers. Monitoring and evaluation of the deferral procedure is of the highest importance to balance blood availability and safety. The aim of the current study was to compare the prevalence of HBV, HCV and HIV serologic markers between deferred donors and eligible blood donors to assess the value of the current donor selection process.
Materials and Methods
Six hundred and nineteen voluntary blood donors in Ahvaz city were included. Serum samples from deferred and eligible donors were examined for serologic markers of HBV, HCV, and HIV using enzyme-linked immunosorbent assay. All positive samples were confirmed using confirmatory tests.
Results
The prevalence rates of HBV infection among deferred and eligible blood donors were estimated to be 0.5% and 0.2%, respectively. Anti-HCV reactivity was detected among 1.3% of deferred blood donors. Moreover, the prevalence of anti-HIV among deferred and eligible blood donors was 0.2% and 0.05%, respectively. We found that the overall prevalence rates of HBsAg, anti-HCV, and anti-HIV in the deferred blood donors are significantly higher than those in the eligible blood donors.
Conclusions
The results of this study indicate the high prevalence rate of blood borne infections. Moreover, it seems that the current donor selection process is effective to identify healthy blood donors. However, the effectiveness of some of the currently used deferral questions in reducing viral risks warrants further study.
E. Samadi, Dr. H. Mirshahabi, Dr. N. Motamed,
Volume 14, Issue 4 (Winter 2017)
Abstract
Abstract
Background and Objectives
Hemodialysis is a major method of treatment for the patients of end-stage renal disease (ESRD). It so disposes them to some infections, specially blood born viruses. The aim of this study was to investigate the prevalence of serological markers for HBsAg, anti-HBs, anti-HCV and HIV Ab in hemodialysis patients in Zanjan city.
Materials and Methods
After 10 ml blood samples were used for detection of markers for hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBs Ab), antibody to HCV (anti-HCV), HIV antibody by ECL. Data were analyzed by c2, t test and fisher exact test.
Results
Positive HBsAg was found in .2.3%, HBs Ab 65.3% and HCV Ab 1.1% of cases. HIV Ab cases were negative in these patients.
Conclusions
The prevalence of HBsAg in hemodialysis patients has been reported to be lower than in the general population. In this study, the prevalence of HBs Ab compared to other studies in Iran and other countries is not much different. The results show that the prevalence of HCV Ab in hemodialysis patients is the same with the general population and the prevalence of HIV Ab in this study is similar to the result recent studies.
Sare Samadi, Dr. Sadegh Shabab, Zahra Arab,
Volume 16, Issue 4 (Winter 2019)
Abstract
Abstract
Background and Objectives
Blood transfusion in critical patients is a lifesaver and at the same time can be fatal due to possible complications. The purpose of this study was to investigate the barriers to reporting the complications of blood transfusion nad the awareness of these complications in nursing staff.
Materials and Methods
A descriptive cross-sectional study was performed on the Mashhad nursing staff in the selected hospital. A population of 120 nursing staff was included in the study. Data collection was done by a researcher-made questionnaire including demographic, knowledge and barrier factors after the confirmation of its validity and reliability. The data were analyzed by SPSS 16.
Results
The mean age was 36 ± 7 years, 56.67% (68) were women, 75.87% (91) had a bachelor's degree and 71.15% (86) were nurses. The legal issues (3.43%), injection of corticosteroids before blood transfusion (3.36%), high inquiries and time consuming forms (3.34%) were major barriers in reporting adverse reactions. The mean knowledge score regarding the recognition of reactions was 85.04% (good) and regarding the care after reactions was 72.79% (moderate). There was no significant relationship between the barriers of reporting adverse reactions and demographic characteristics.
Conclusions
It is necessary to provide training on the detection of the transfusion reactions and its importance. There is also a need to take steps to encourage staff to report, ensure non-punishment approach to reporting reactions and errors, facilitate reporting, and simplify design of the reporting form to pave the way for reporting reactions of blood transfusions.
M. Samadi Ivriq, Dr. A. Oodi, Dr. B. Keikhaei , Dr. S. Mohammadi,
Volume 20, Issue 3 (َAutumn 2023)
Abstract
Abstract
Background and Objectives
Sickle Cell Disease is the second most common hemoglobinopathy after thalassemia and is characterized by vascular occlusion and hemolytic anemia. Blood transfusion is considered as a supportive treatment for patients with sickle cell disease. The alloimmunization of red blood cells is a major challenge in these patients. Accordingly, supplying the appropriate antigen-negative blood units is a major problem in blood transfusion. The aim of this study was to evaluate the alloimmunization rates among individuals with Sickle Cell Disease in Khuzestan province.
Materials and Methods
In this descriptive cross-sectional study, a total of 184 patients with sickle cell anemia and sickle-thalassemia were referred to the Shahid Beqaei hospital in Ahvaz. 5-10 mL of peripheral blood containing the anticoagulant EDTA was collected by non-random sampling procedure. The prevalence of phenotypes and the rate of alloimmunization were determined by the hemagglutination technique.
Results
The prevalence of alloimmunization in this population was 13.0%. In 24 patients, twelve types of alloantibodies were detected. The most common alloantibodies were Anti-E (33.3%, n = 8), Anti-c (20.8%, n = 5), Anti-D (16.6%, n = 4), and Anti- Kell (16.6%, n = 4).
Conclusions
Antibody against Rh blood group system and anti-Kell were the most prevalent alloantibodies among sickle cell anemia patients in the province of Khuzestan. Therefore, it is highly recommended to transfuse these individuals with blood units compatible with the Rh (D, C, c, and E) and Kell antigens.
