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Showing 2 results for Heidari Soureshjani
Prevalence of various mutations in Beta thalassaemia in Province of Chahar Mahal Bakhtiari and Isfahan and its association with haematological parameters
E. Heidari Soureshjani, S. Vallian, S.f. Mirahmadi Babaheidari, F. Abasian,
Volume 14, Issue 2 (Summer 2017)
Abstract

Abstract

Background and Objectives

There is considerable phenotypic variation of Beta-thalassemia with common mutations whose understanding would facilitate the prevention of the specific syndromes. The aim of this study was to determine the common Beta-thalassemia mutations in Isfahan and Chaharmahal Bakhtiari province and thier relationship with blood parameters.

Materials and Methods

In this descriptive study, 10 ml venous blood samples were taken from 321 Beta thalassemia carriers having referred to the private Isfahan Center of Medical Genetics in 2016. For the confirmation of the diagnosis of Beta thalassemia in these patients, the indices of MCV and MCH with Mindary device and HbA1, HbA2, Hbf and RBC with the electrophoresis method were measured. c2, t-test and SPSS 22 were used in analyzing data.

Results

Mutation Fr36/37 (-T) in the population studied in Isfahan and Chaharmahal Bakhtiari with the frequency rates of 34 (26.35%) and 22 (32.35%) showed the highest in the studied mutations. About 80% of cases were detectable mutations in the beta globin gene in the people with HbA2 > 3.5 and in 100% of cases with MCH < 27 and MCV < 80.

Conclusions 

Beta-thalassemia mutations among Chaharmahal Bakhtiari and Isfahan populations show diversity and wide distribution. Average mutations studied based on blood indices showed a wide variety. The results showed a positive correlation between beta-thalassemia mutations and red blood cells indices which can be effective in fast and efficient screening of these common mutations.


Molecular Detection of HCV and HBV in HIV positive patients in Chaharmahal and Bakhtiari Province
Farzaneh Taheri Ghahfarkhi, Dr. E. Tajbakhsh, E. Heidari Soureshjani,
Volume 15, Issue 4 (Winter 2018)
Abstract
Abstract
Background and Objectives
Viral hepatitis B and C are considered to be a medical problem for people with HIV infection. The importance of these infections is in the shared route of their transmission, and liver disease as a result of infection with HCV, HBV and HIV infection that can lead to death.
 
Materials and Methods
In this cross-sectional descriptive study, a total of 31 serum samples were prepared from patients referring to the Behavioral Diseases Counseling Center in Chaharmahal and Bakhtiari province who were diagnosed with HIV infection by Western blotting method; their consent was taken. The coinfection with HBV and HCV was investigated by PCR method. Data were analyzed by fisher exact test and prism7 software.
 
Results
The results of this study on serum samples of HIV-infected people showed the prevalence of HCV/HBV coinfection in HIV-positive individuals to be %3.22, the prevalence of HBV infection in HIV-positive individuals %4.45, and the prevalence of HCV infection in HIV infected ones %22.5.
 
Conclusions 
According to the common routes of transmission of HCV, HBV, and HIV viruses, it is essential that all people who are HIV-positive or HIV-infected be screened for hepatitis B and C viruses by highly sensitive diagnostic methods.
 
 

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