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Sci J Iran Blood Transfus Organ 2015, 11(1): 41-47 Back to browse issues page
Comparison of effectiveness of shot-time iron supplements with iron plus Vitamin C on compensating of Iron loss in female blood donors in Isfahan
N. Akbari, M. Maghsudlu, S.H. Tabibpour, M. Mehran, A. Sadeghi, A.R. Ebrahimian
Keywords: Key words: ferrous sulfate, Anemia, Iran, Blood Donors
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Type of Study: Research | Subject: Blood donation
Published: 2014/03/16
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Original Article
Sci J Iran Blood Transfus Organ 2014; 11(1): 41-47


 Comparison of effectiveness of shot-time iron supplements
with iron plus Vitamin C on compensating of Iron loss
in female blood donors in Isfahan
Akbari N.1,2, Maghsudlu M.1, Tabibpour S.H.1,2, Mehran M.1, Sadeghi A.1,2, Ebrahimian A.R.1,3
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Isfahan Regional Educational Blood Transfusion Center, Isfahan, Iran
3Tehran Regional Educational Blood Transfusion Center, Tehran, Iran
Background and Objectives
Iron deficiency anemia might appear in donors particularly in women following blood donation. The present study compared the efficacy and consequences of iron intake compared with iron plus vitamin C supplements.
Materials and Methods
One hundred thirty eligible female donors were included in the study. The iron supplement group (IS) receiving 150 mg/day in a 10-day course of oral ferrous sulfate, divided in 3 doses were compared with the group who received  iron supplement plus vitamin C (750 mg/day) in a 10-day course, divided in 3 doses, orally (AIS group). Ferritin, hemoglobin, hematocrit, serum iron, and total iron binding capacity (TIBC) were checked in both groups at the first visit before donation and 4 months after donation.
TIBC levels increased in both groups of donors (p< 0.01). Ferritin level in IS group decreased (p= 0.036)  from 25 ± 24 (ng/ml ) to 22 ± 21, and in AIS group (p= 0.031) from 16.5 ± 17 to 13.5 ± 13 after donation. Iron storage levels were similar in the both groups (p> 0.05). Gastrointestinal disturbances was seen in 9% (12) of supplement consumers. There are no differences between the two groups (p< 0.05).
Addition of Vitamin C to ferrous sulfate supplements neither had any impact on body iron load nor placed any adverse effects on blood donors. Moreover, the decline of ferritin level in all volunteers might be due both to the time duration between the first and the second sampling and the menstural period.
Key words: ferrous sulfate,  Anemia, Iran, Blood Donors
Received:   3 Sep 2011
Accepted: 14 Oct 2013

Correspondence: Akbari N., MD. Blood Transfusion Research Center, High Institute for Research and Education in
Transfusion Medicine and Isfahan Regional Educational Blood Transfusion Center.
P.O. Box: 81688-44861, Isfahan, Iran. Tel: (+98311) 2607074; Fax : (+98311) 2607074
E-mail: nah_akbari@yahoo.com
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Akbari N, Maghsudlu M, Tabibpour S, Mehran M, Sadeghi A, Ebrahimian A. Comparison of effectiveness of shot-time iron supplements with iron plus Vitamin C on compensating of Iron loss in female blood donors in Isfahan. Sci J Iran Blood Transfus Organ 2015; 11 (1) :41-47
URL: http://bloodjournal.ir/article-1-854-en.html

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Volume 11, Issue 1 (Spring 2014 2015) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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