:: Volume 2, Issue 5 (Autumn 2005) ::
Sci J Iran Blood Transfus Organ 2005, 2(5): 163-169 Back to browse issues page
Evaluation of platelet activation in platelet concentrates during storage in the Quality Control Laboratory of Iranian Blood Transfusion Organization in 2004
A. Solaimany Ferizhandy, M. Aghaeipour, A.A. Pourfathollah
Abstract:   (12759 Views)

  Abstract

  

 Background and Objectives

  Conditions for preparation and storage of platelets for transfusion purposes may lead to platelet activation which in turn contributes to decreased ability of stored platelets to function and to survive in vivo after transfusion as compared with freshly prepared platelets. We investigated platelet membrane expression of CD62P, CD63 in platelet stored for up to 3 days under standard blood banking conditions.

  

  Materials and Methods 

  Twenty-four platelet units prepared by platelet-rich-plasma and platelet concentrates were evaluated during storage for markers CD62P, CD63 and pH.

 

 Results

 During storage for up to 3 days platelet units displayed no significant pH (p>0.05). During storage for up to 3 days (days 1 and 3) platelet units were significant in the CD62P and CD63 expressions as compared with day 0 (p<0.05).

  

 Conclusions

 Storage of platelet concentrates causes activated platelets. Moreover, these markers (CD62P and CD63) can act as useful in vitro means in the quality control of platelet components.

  

  

 Key words: Platelet-rich-plasma, CD62P, CD63

Keywords: Platelet-rich-plasma, CD62P, CD63
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Type of Study: Research | Subject: General
Published: 2014/06/30


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Volume 2, Issue 5 (Autumn 2005) Back to browse issues page