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:: Volume 6, Issue 2 (Summer 2009) ::
Sci J Iran Blood Transfus Organ 2009, 6(2): 85-93 Back to browse issues page
L-Asparginase effect with 6000U/m2 on lipid profile in children with acute lymphoblastic leukemia
MT. Arzanian , A. Eghbali, S. Alavi, B. Sh. Shamsian, F. Malek, E. Azargashb
Abstract:   (16632 Views)

  Abstract

 Background and objectives

 One of the major etiologies of lipid disorders in malignancies is the use of chemotherapy drugs, the most important of which is L-Asparginase. Studies in different centers with high dosages of L-Asparginase demonstrated different results. The aim of this study is to evaluate the effect of L-Asparginase at a dose of 6000 U/m2 on lipid profile in Iranian children with newly diagnosed acute lymphoblastic leukemia in Mofid Children Hospital of Tehran .

 

 Materials and Methods

 We performed a nonrandomized trial in which all children with newly diagnosed acute lymphoblastic leukemia (ALL) aged <15 years participated. Every case serves as his/her own control. The cholesterol, triglyceride (TG), HDL, LDL, VLDL, APOA, APOB and LPa were evaluated in three stages: before, during and 2 months after treatment with L-Asparginase after which the results were compared.

 

 Results

 In our study, 82 newly ALL diagnosed patients with the mean age of 6 years (within the age range of 0.12-14 and SD of 3.5) were evaluated. Mean seum level of TG in pretreatment stage was 163.9 mg% and during treatment with L-Asparginase 123 mg% demonstrating significant decline in TG serum level after administration of L-Asparginase (p=0.002). Mean serum level of cholesterol before administration of L-Asparginase was 151mg% and during treatment 140 showing no statistically significant difference (p= 0.061). LPa level in pretreatment phase was 24mg% and during treatment 14 showing a statistically significant difference (p= 0.0001).

 

 Conclusions

 L-Aspar resulted in decline in TG serum level and increase in HDL though with no significant difference in cholesterol level. Overall, L-Asparginase even at a dose of 6000U/M2 does not raise blood level of triglyceride and cholesterol.

 

 Key words : Leukemia, Lymphoblastic, Acute, L-Asparagine, children

Keywords: Leukemia, Lymphoblastic, Acute, L-Asparagine, children
Full-Text [PDF 256 kb]   (1932 Downloads)    
Type of Study: Research | Subject: Hematology and Oncology
Published: 2014/08/16
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Arzanian M, Eghbali A, Alavi S, Shamsian B S, Malek F, Azargashb E. L-Asparginase effect with 6000U/m2 on lipid profile in children with acute lymphoblastic leukemia. Sci J Iran Blood Transfus Organ. 2009; 6 (2) :85-93
URL: http://bloodjournal.ir/article-1-319-en.html


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Volume 6, Issue 2 (Summer 2009) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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