Volume 20, Issue 3 (َAutumn 2023)                   Sci J Iran Blood Transfus Organ 2023, 20(3): 255-265 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Pourmokhtar M. The role of platelet products in the treatment of microbial infections. Sci J Iran Blood Transfus Organ 2023; 20 (3) :255-265
URL: http://bloodjournal.ir/article-1-1485-en.html
The role of platelet products in the treatment of microbial infections
Mojgan Pourmokhtar *
Keywords: Key words: Platelets, Platelet-Rich Plasma, Anti-Infective Agents
Full-Text [PDF 378 kb]   (516 Downloads)     |   Abstract (HTML)  (854 Views)
Full-Text:   (544 Views)
References:
  1. Michelson AD, Cattaneo M, Frelinger AL, Newman PJ. Platelets. 4th ed. UK: Academic Press; 2019. p. 160-70.
  2. Manasa K, Vani R. Influence of Oxidative Stress on Stored Platelets. Adv Hematol 2016; 2016: 4091461.
  3. Handigund M, Cho YG. Insights into platelet storage and the need for multiple approaches. Ann Clin Lab Sci 2015; 45(6): 713-9.
  4. Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int J Mol Sci 2020; 21(20): 7794. 
  5. Yuan S, Goldfinger D. Clinical and laboratory aspects of platelet transfusion therapy. www.uptodate.com. Accessed 26 August 2015.
  6. El-Sharkawy H, Kantarci A, Deady J, Hasturk H, Liu H, Alshahat M, et al. Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties. J Periodontol 2007; 78(4): 661-9.
  7. Assoian RK, Grotendorst GR, Miller DM, Sporn MB. Cellular transformation by coordinated action of three peptide growth factors from human platelets. Nature 1984; 309 (5971): 804-6.
  8. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003; 83(3): 835-70.
  9. Toscano N, Holtzclaw D. Sugical considerations in the use of platelet-rich plasma. Compend Contin Educ Dent 2008; 29(3): 182-5.
  10. Tang YQ, Yeaman MR, Selsted ME. Antimicrobial peptides from human platelets. Infect Immun 2002; 70(12): 6524-33.
  11. Yeaman MR. The role of platelets in antimicrobial host defense. Clin Infect Dis 1997;  25(5): 951-68.
  12. Joseph M. The generation of free radicals by platelets. In: Joseph M, editor. Immunopharmacology of platelets. 1st ed. London: Academic Press; 1995. p. 209-25.
  13. Dziarski R, Gupta D. Mammalian PGRPs: novel antibacterial proteins. Cell Microbiol 2006; 8(7): 1059-69.
  14. Vasina EM, Cauwenberghs S, Feijge MA, Heemskerk JW, Weber C, Koenen RR. Microparticles from apoptotic platelets promote resident macrophage differentiation. Cell Death Dis 2011; 2(9): e211.
  15. Rostami S, Pourmokhtar M. In vitro Evaluation of the antibacterial activity of Platelet-rich Plasma against Selected Oral and Periodontal Pathogens. IJBC 2018; 10(2): 35-8.
  16. Jafarzadeh E, Pourmokhtar M, Tavili S. In Vitro Evaluation of the Anti-bacterial Effect of Human Platelet Concentrate. IJBC 2016; 8(1): 5-8.
  17. Feng M, Wang Y, Zhang P, Zhao Q, Yu S, Shen K, et al. Antibacterial effects of platelet-rich fibrin produced by horizontal centrifugation. Int J Oral Sci 2020; 12(1): 32.
  18. Jasmine S, Thangavelu A, Janarthanan K, Krishnamoorthy R, Alshatwi AA. Antimicrobial and antibiofilm potential of injectable platelet rich fibrin second-generation platelet concentrate-against biofilm producing  oral  staphylococcus   isolates.  Saudi J Biol Sci 2020; 27(1): 41-6.
  19. Smith OJ, Wicaksana A, Davidson D, Spratt D, Mosahebi A. An evaluation of the bacteriostatic effect of platelet-rich plasma. Int Wound J 2021; 18(4): 448-56.
  20. Yeaman MR. Platelets: at the nexus of antimicrobial defense. Nat Rev Microbiol 2014; 12(6): 426-37.
  21. Yeaman MR. Platelets in defense against bacterial pathogens. Cell Mol Life Sci 2010; 67: 525-44.
  22. Bielecki TM, Gazdzik TS, Arendt J, Szczepanski T, Krol W, Wielkoszynski A. Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study. J Bone Joint Surg Br 2007; 89: 417-20.
  23. Moojen DJ, Everts PA, Schure M, Overdevest EP, van Zundert A, Knap JT, et al. Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus. J Orthop Res 2008; 26: 404-10.
  24. Intravia J, Allen DA, Durant TJ, McCarthy MB, Russell R, Beitzel K, et al. In vitro evaluation of the anti-bacterial effect of two preparations of platelet rich plasma compared with cefazolin and whole blood. Muscle Ligament Tendon J 2004; 4(1): 79-84.
  25. Wang Q, Qian Z, Liu B, Liu J, Zhang L, Xu J. In vitro and in vivo evaluation of new PRP antibacterial moisturizing dressings for infectious wound repair. J Biomater Sci Polym 2019; 30: 462-85.
  26. Li T, Ma Y, Wang M, Wang T, Wei J, Ren R. Platelet-rich plasma plays an antibacterial, anti-inflammatory and cell proliferation promoting role in an in vitro model for diabetic infected wounds. Infect Drug Resist 2019; 12: 297-309.
  27. Fabbro MD, Bortolin M, Taschieri S, Ceci C, Weinstein RL. Antimicrobial properties of platelet-rich preparations A systematic review of the current pre-clinical evidence. Platelets 2016; 27(4): 276-85.
  28. Zhang W, Guo Y, Kuss M, Shi W, Aldrich AL, Untrauer J, et al. Platelet-rich plasma for the treatment of tissue infection: Preparation and clinical evaluation. Tissue Eng Part B Rev 2019; 25(3): 225-236.
  29. Cetinkaya RA, Yenilmez E, Petrone P. Platelet rich plasma as an additional therapeutic option for infected wounds with multi-drug resistant bacteria: In vitro antibacterial activity study. Eur J Trauma Emerg Surg. 2019; 45(3): 555-65.
  30. Aggour R, Gamil L. Antimicrobial effects of platelet-rich plasma against selected oral and periodontal pathogens. Pol J Microbiol 2017; 66(1): 31-7.
  31. Mariani E, Filardo G, Canella V. Platelet-rich plasma affects bacterial growth in vitro. Cytotherapy 2014; 16(9): 1294-304.
  32. Badade P, Mahale S, Panjwani A, Vaidya P, Warang A. Antimicrobial effect of platelet-rich plasma and platelet-rich fibrin. Indian J Dent Res 2016; 27(3): 300-4.
  33. Cieslik-Bielecka A, Bold T, Ziolkowski G, Pierchala M, Krolikowska A, Reichert P. Antibacterial activity of leukocyte and platelet-rich plasma: An in vitro study. Biomed Res Int 2018; 2018: 9471723.
  34. Yang LC, Hu SW, Yan M, Yang JJ, Tsou SH, Lin YY. Antimicrobial activity of platelet-rich plasma and other plasma  preparations  against  periodontal  pathogens. J Periodontol 2015; 86(2): 310-8.
  35. Clawson CC, Rao GHR, White JG. Platelet interaction with bacteria. IV. Stimulation of the release reaction. Am J Pathol 1975; 81: 411-20.
  36. Michelson AD. Platelets. 3rd ed. San Diego, CA: Academic Press;  2013. p. 240.
  37. Drago L, Bortolin M, Vassena C, Taschieri S, Del Fabbro M. Antimicrobial activity of pure platelet-rich plasma against microorganism isolated from oral cavity. BMC Microbiol 2013; 13: 47-51.
  38. Burnouf T, Chou ML, Wu YW, Su CY, Lee LW. Antimicrobial activity of platelet (PLT)-poor plasma, PLT-rich plasma, PLT gel, and solvent/detergent-treated PLT lysate biomaterials against wound bacteria. Transfusion 2013; 53(1): 138-46.
  39. Li H, Li B. PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP.  J Vis Exp 2013; (74): 50351. 
  40. Yuan T, Zhang CQ, Tang MJ, Guo SC, Zeng BF. Autologous Platelet-rich Plasma Enhances Healing of Chronic Wounds. WOUNDS 2009; 21(10): 280-5.
  41. Hom DB, Linzie BM, Huang TC. The Healing Effects of Autologous Platelet Gel on Acute Human Skin Wounds. Arch Facial Plast Surg 2007;  9(3): 174-83.
  42. Geremicca W, Fonte C, Vecchio S. Blood components for topical use in tissue regeneration: evaluation of corneal lesions treated with platelet lysate and considerations on repair mechanisms. Blood Transfus 2010; 8(2): 107-12.
  43. Anitua E, Alonso R, Girbau C, Aguirre JJ, Murozabal F, Orive G. Antibacterial effect of plasma rich in growth factors (PRGF-Endoret) against Staphylococcus aureus and Staphylococcus epidermidis strains. Clin Exp Dermatol 2012; 37(6): 652-7.
  44. Cieslik-Bielecka A, Dohan Ehrenfest DM, Lubkowska A, Bielecki T. Microbicidal properties of Leukocyte and Platelet-Rich Plasma/Fibrin (L-PRP/L-PRF): new perspectives. J Biol Regul Homeost Agents 2012; 26(2 Suppl 1): 43S-52S.
  45. Andersson DI, Hughes D Persistence of antibiotic resistance in bacterial populations. FEMS Microbiol Rev 2011; 35(5): 901-11.
  46. Youssefian T, Drouin A, Masse JM. Host defense role of platelets: Engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation. Blood 2002; 99: 4021-9.
  47. Deppermann C, Kubes P. Start a fire, kill the bug: The role of platelets in inflammation and infection. Innate Immun 2018;  24(6): 335-48.
  48. Newton, K.; Dixit, V.M. Signaling in Innate Immunity and Inflammation. Cold Spring Harb Perspect Biol 2012; 4(3): a006049.
  49. Cognasse F, Laradi, S Berthelot P, Bourlet, Marotte H, Mismetti P, et al. Platelet Inflammatory Response to Stress. Front. Immunol 2019; (10): 1478.
  50. Clemetson K, Clemetson J, Proudfoot A, Power C, Baggiolini M, Wells T. Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets. Blood 2000; 96: 4046-54.
  51. Gros  A,  Syvannarath V, Lamrani L, Ollivier V, Loyau S, Goerge T et al. Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex–mediated  inflammation in mice. Blood 2015; 126: 1017-26.
  52. Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 2007; 13: 463-9.
  53. Woodell-May JE, Sommerfeld SD. Role of Inflammation and the Immune System in the Progression of Osteoarthritis. J Orthop Res 2020; 38: 253-7.
  54. Semple JW, Italiano JE, Freedman J. Platelets and the immune continuum. Nat Rev Immunol 2011; 11: 264-74.
  55. Xu Y, Yu H, Sun H. Targeting the host hemostatic system function in bacterial infection for antimicrobial therapies. J Thromb Thrombolysis 2014; 37: 66-73.
  56. Bayer A, Lammel J, Rademacher F, Grob J, Siggelkow M, Lippross S, et al. Platelet-released growth factors induce the antimicrobial peptide human beta-defensin-2 in primary keratinocytes. Exp Dermatol 2016; 25: 460-5.
  57. Shannon O. Determining platelet activation and aggregation in response to bacteria. Methods Mol Biol 2017; 1535: 267-73.
  58. Tohidnezhad M, Varoga D, Podschun R, Wruck CJ, Seekamp A, Brandenburg LO, et al. Thrombocytes are effectors of the innate immune system releasing human beta defensin-3. Injury 2011; 42: 682-6.
  59. Yeaman MR. Antimicrobial peptides from platelets in defense against cardiovascular infections. In: Devine DA, Hancock REW (eds) Mammalian host defense peptides. Cambridge University Press, Cambridge; 2004. p. 279-322.
  60. Zhang G, Han J, Welch EJ, Ye RD, Voyno-Yasenetskaya TA, Malik AB, et al. Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. J Immunol 2009; 182(12): 7997-8004.
  61. Everts PA, Hoffmann J, Weibrich G, Mahoney CB, Schonbergr PAM, van Zundert A, et al. Differences in platelet growth factor release and leucocyte kinetics during autologous platelet gel formation. Transfus Med 2006; 16: 363-8.
  62. Aktan I, Dunkel B, Cunningham FM. Equine platelets inhibit E. coli growth and can be activated by bacterial lipopolysaccharide and lipoteichoic acid although superoxide anion production does not occur and platelet activation is not associated with enhanced production       by       neutrophils.     Vet         Immunol Immunopathol 2013; 152: 209-17.
  63. Lacci KM, Dardik A. Platelet-rich plasma: support for its use in wound healing. Yale J Biol Med 2010;  83: 1-9.
  64. Frelinger AL 3rd, Torres AS, Caiafa A, Morton CA, Berny-Lang MA, Gerrits AJ, et al. Platelet-rich plasma stimulated by pulse electric fields: platelet activation, procoagulant markers, growth factor release and cell proliferation. Platelets 2016;  27: 128-35.
  65. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004;  91(1): 4-15.
  66. Filardo  G,   Previtali     D,   Napoli   F,    Candrian    C, Zaffagnini S, Grassi A. PRP Injections for the Treatment of Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials. Cartilage 2021; 13(1_suppl): 364S-375S.
  67. Andia I, Rubio-Azpeitia E, Martin JI, Abate M. Current Concepts and Translational Uses of Platelet Rich Plasma Biotechnology. In: Ekinci D (ed). Biotechnology. InTech; 2015.  p. 1-31.
  68. Monteiro MR. Platelet rich plasma in dermatology. Surg Cosmet Dermatol 2013; 5(2): 155-9.
  69. Lindeboom JA, Mathura KR, Aartman IH, Kroon FH, Millstein DM, Ince C. Influence of the application of platelet-enriched plasma in oral mucosal wound healing. Clin Oral Implants Res 2007; 18(1): 133-9.
  70. Wrotniak M, Bielecki T, Gazdzik TS. Current opin­ion about using the platelet-rich gel in orthopaedics and trauma surgery. Ortop Traumatol Rehabil 2007; 9: 227-38.
  71. Yol S, Tekin A, Yilmaz H, Küçükkartallar T, Esen H, Caglayan O, et al. Effects of platelet rich plasma on colonic anastomosis. J Surg Res 2008; 146(2): 190-4.
  72. Aleksic  Z.  Clinical  impact  of  platelet  rich plasma in treatment of gingival recessions. Srp Arh Celok Lek 2008; 136(3-4): 95-103.
  73. Ebisawa K, Kato R, Okada M, Kamei Y, Mazlyzam AL, Narita Y, et al. Cell therapy for facial anti-aging. Med J Malaysia 2008; 63(Suppl A): 41.
  74. Simman R. Role of platelet-rich plasma in acceleration of bone fracture healing. Ann Plast Surg 2008; 61(3): 337-44.
  75. Wu W. Platelet-rich plasma-A promising cell carrier for micro-invasive articular carilage repair. Med Hypotheses 2009; 72(4): 455-7.
  76. Amable PR, Carias RB, Teixeira MV, da Cruz Pacheco I, Corrêa do Amaral RJ, Granjeiro JM, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther 2013; 4(3): 67.
  77. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte-and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009; 27(3): 158-67.
  78. Jameson CA. Autologous Platelet Concentrate for the Production of Platelet Gel. LabMedicine 2007; 38: 39-42.
  79. Filardo G, Di Matteo B, Kon E, Merli G, Marcacci M. Platelet-rich plasma in tendon-related disorders: Results and indications. Knee Surg. Sports Traumatol. Arthrosc 2016; 26: 1984-99.
  80. Belk JW, Kraeutler MJ, Houck DA, Goodrich JA, Dragoo JL, McCarty EC. Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Am J Sports Med 2021; 2021; 49(1): 249-260. 
  81. Xuan Z, Yu W, Dou Y, Wang T. Efficacy of Platelet-rich Plasma for Low Back Pain: A Systematic Review and Meta-analysis. J Neurol Surg. Part A Central Eur Neurosurg 2020;  81(6): 529-34.
  82. Strauss  FJ, Stähli A, Gruber R. The use of platelet rich fibrin  to   enhance  the  outc omes of implant therapy: A  systematic  review.  Clin Oral Implant Res 2018; 29:6-19.
  83. Everts PA. Autologous Platelet-Rich Plasma and Mesenchymal Stem Cells for the Treatment of Chronic Wounds. In Wound Healing-Current Perspectives; Hakan Dogan K, Ed.; IntechOpen: London, UK. 2019. p. 124-30.
  84. Andia I, Maffulli N. A contemporary view of platelet-rich plasma therapies: Moving toward refined clinical protocols and precise indications. Regen Med 2018; 13: 717-28.
  85. Haunschild ED, Huddleston HP, Chahla J, Gilat R, Cole BJ, et al. Platelet-Rich Plasma Augmentation in Meniscal Repair Surgery: A Systematic Review of Comparative Studies. Arthrosc J Arthrosc Relat Surg 2020; 36: 1765-74.
  86. Smith OJ, Jell G, Mosahebi A. The use of fat grafting and platelet-rich plasma for wound healing: A review of the current evidence. Int Wound J 2019;  16(1): 275-85.
  87. Pourmokhtar M, Abedi M. Skin rejuvenation using platelet-rich plasma products. Razi J Med Sci 2020; 27(8): 1-9. [Article in Farsi]
  88. Leo MS, Kumar AS, Kirit R,   Konathan  R, Sivamani RK. Systematic review of the use of platelet-rich plasma in aesthetic dermatology. J Cosmet Dermatol 2015; 14(4): 315-23.
  89. Pourmokhtar M, Jalili MA, Rafiei MH, Deihim MR, Samiei S, khoshnaghsh F. Basic and applied concepts in platelets: The biochemical approach. 1st ed. Tehran: Zohd-IBTO; 2016. p. 71-122. [Persian]
  90. Pourmokhtar M, Salek Moghaddam E, Abbasi F, Zarei N. Comparative Study of Four Platelet-Rich Plasma Methods for Preparing Platelet Concentrates.  IJBC 2014; 3: 103-7.
  91. Vassallo RR, Murphy S. A critical comparison of platelet preparation methods. Curr Opin Hematol. 2006; 13(5): 323-30.
  92. Tynngård N. Preparation, storage and quality control of platelet concentrates. Transfus Apher Sci 2009; 41(2): 97-104.
  93. Beitzel K, Allen D, Apostolakos J, Russell R, McCarthy M, Gallo GJ, et al. US Definitions, Current Use, and FDA Stance on Use of Platelet-Rich Plasma in Sports Medicine. J Knee Surg 2014; 28: 29-34.
  94. Blaney KD, Howard PR. Basic & Applied Concepts of Blood Banking and Transfusion Practices. 3rd ed. Maryland Heights, MO: Mosby; 2012. p. 43-65.
  95. Murphy S. Platelet storage for transfusion. Semin Hematol 1985; 22(3): 165-77.
  96. Sethi D, Martin KE, Shrotriya S.  Brown BL. Systematic literature review evaluating evidence and mechanisms of action for platelet-rich plasma as an antibacterial agent. J Cardiothorac Surg 2021; 16(1): 277. 
  97. Wiens L, Lutze G, Luley C, Westphal S. Platelet count and platelet activation: Impact of a fat meal and day time. Platelets 2007; 18(2): 171-3.
  98. Li M, Zhang C, Yuan T, Chen S, Lü R. Assessment study on a set of platelet-rich plasma preparation. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2011; 25(1): 112-6.
  99. Arnoczky SP, Delos D, Rodeo SA. What Is Platelet- Rich Plasma? Oper Tech Sports Med 2011; 19: 142-8.
  100. Sundman EA, Cole BJ, Fortier LA. Growth Factor and Catabolic Cytokine Concentrations Are Influenced by the Cellular Composition of Platelet-Rich Plasma. Am J Sport Med 2011;  39: 2135-40.
  101. Tohidnezhad M, Varoga D, Wruck CJ, Podschun R, Sachweh BH, Bornemann J, et al. Platelets display potent antimicrobial activity and release human beta-defensin 2. Platelets 2012; 23: 217-23.
  102. Farghali HA, AbdElKader NA, AbuBakr HO, Aljuaydi SH, Khattab MS, Elhelw R, et al. Antimicrobial action of autologous platelet-rich plasma on MRSA-infected skin wounds in dogs. Sci Rep 2019;  9(1): 12722.
  103. Smith OJ, Wicaksana A, Davidson D, Spratt D, Mosahebi A. An evaluation of the bacteriostatic effect of platelet-rich plasma. Int Wound J 2021; 18(4): 448-456.
  104. Krijgsveld J, Zaat SA, Meeldijk J, Van Veelen PA, Fang G, Poolman B, et al. Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of Cxc chemokines. J Biol Chem 2000;  275(27): 20374-81.
  105. Radek K, Gallo R. Antimicrobial peptides: Natural effectors of the innate immune system. Semin Immunopathol 2007; 29(1): 27-43.
  106. Blair P, Flaumenhaft R. Platelet alpha-granules: Basic biology and clinical correlates. Blood Rev 2009; 23: 177-89.
  107. Jianguo C, Yingying W, Yan L, Haiyue J. The application of platelet-rich plasma for skin graft enrichment: A meta-analysis. Int Wound J 2020; 17: 1650-8.
Type of Study: Review Article | Subject: Blood transfusion medicine
Published: 2023/09/1
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Scientific Journal of Iran Blood Transfus Organ

Designed & Developed by : Yektaweb