:: Volume 18, Issue 2 (Summer 2021) ::
Sci J Iran Blood Transfus Organ 2021, 18(2): 142-147 Back to browse issues page
A Case Report of Acute T Cell Lymphoblastic Leukemia with Complex Chromosomal Abnormalities in a Child with Ataxia Telangiectasia
M. Safavi , A. Safaei, Gh.R. Fathpour
Abstract:   (303 Views)
 
Abstract
Background and Objectives
Ataxia telangiectasia is a disease with chromosomal instability that causes susceptibility to malignancy.
 
Case
The patient was a 7-year-old boy living in Shiraz who had ataxia telangiectasia and was hospitalized due to fever and lymphadenopathy. Bone marrow aspiration showed a 60% blast population that was consistent with acute T cell lymphoblastic leukemia, immunophenotypically. In cytogenetic examination of bone marrow aspiration, complex chromosomal abnormalities as 42,XY,-5,del(6)(q22),der(8)t(8;17)(q24;q12~q22),t(9;16) (q12;q24),dic(12;14)(p11;q24),+13,-14,-22 were observed. Despite chemotherapy, the patient expired after two relapses of leukemia.
 
Conclusions 
T cell acute lymphoblastic leukemia due to ataxia telangiectasia  can be associated with complex karyotype abnormalities leading to leukemia relapse and adverse prognosis.

Keywords: Ataxia Telangiectasia, Cytogenetic Aberrations, Leukemia
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Type of Study: case report | Subject: Hematology and Oncology
Published: 2021/07/1


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Volume 18, Issue 2 (Summer 2021) Back to browse issues page