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Sci J Iran Blood Transfus Organ 2021, 18(4): 233-240 Back to browse issues page
Assessment of the prevalence of non-alcoholic fatty liver disease in regular and non-regular blood and plasma donors
M.R. Sasani, M. Izadi
Keywords: Key words: Liver Diseases, Prevalence, Blood Donation
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Type of Study: Research | Subject: Blood transfusion medicine
Published: 2021/12/31
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Sci J Iran Blood Transfus Organ 2021;18 (4): 233-240
Original Article
 
 
 
 
 


Assessment of the prevalence of non-alcoholic fatty liver
disease in regular and non-regular blood
and plasma donors
 
Sasani M.R.1, Izadi M.2,3
 
 
1Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
3Shiraz Regional Educational Blood Transfusion Center, Shiraz, Iran
 
Abstract
Background and Objectives
Non-alcoholic liver disease (NAFLD) is a spectrum of diseases, ranging from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH) which can lead to liver cirrhosis and hepatocellular carcinoma. Nonalchololic fatty liver  is the most prevalent hepatic disorder worldwide which can affect up to the one out of four adults. Little is known about the prevalence of nonalchololic fatty liver among regular donors of blood products. The current study shows the prevalence of nonalchololic fatty liver  in regular plasma and blood donors with a discontinuous donor population.
 
Materials and Methods
In this case-control study, we non-randomly enrolled 400 volunteers of blood donors who met the blood donation criteria after signing the written informed consent. All patients underwent hepatobiliary ultrasonography to evaluate fatty liver. LFT (Liver Function Test) and demographic criteria had been submitted in data base. All data were described by central dispersion indices and analyzed by Mann-Whitney U test and chi-square.
 
Results
No difference was seen regarding gender and mean age between groups (p-value of 0.441 and 0.635, respectively). According to univariate analysis there was no significant difference between the two groups regarding the prevalence of fatty liver (p= 0.264) or its staging (p= 0.9). In addition, OR and RR were 1.17 and 1.11, respectively; both not being significant (p= 0.461).
 
Conclusions 
The prevalence of NAFLD has no significant correlation with both regular blood donors and non-regular blood donors.
 
Key words: Liver Diseases, Prevalence, Blood Donation
 
 
 
 
Received:  7 Mar 2021
Accepted: 4 Sep 2021
 
 

Correspondence:Izadi M., Radiologist. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine and Shiraz Blood Transfusion Center.
P.O.Box: 1153, Shiraz,  Iran. Tel: (+9871) 6273445; Fax: (+9871) 6264006
E-mail: ifatemeh241@gmail.com
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Sasani M, Izadi M. Assessment of the prevalence of non-alcoholic fatty liver disease in regular and non-regular blood and plasma donors. Sci J Iran Blood Transfus Organ 2021; 18 (4) :233-240
URL: http://bloodjournal.ir/article-1-1393-en.html


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Volume 18, Issue 4 (Winter 2021) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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