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Role of HLA-G 14 bp Indel polymorphism on susceptibility to HTLV-1 infection in blood donors of Khorasan Razavi Blood Center
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Z. Ganjian Mofrad   , A. Arabkhazaeli  , F. Mollahoseini , M. Shahabi * |
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| Keywords: HTLV-1, Infection, HLA-G |
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Type of Study: Research |
Subject:
Infectious disease
Published: 2022/03/30
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Full-Text: (671 Views) |
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Sci J Iran Blood Transfus Organ 2022;19 (1): 24-29
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Role of HLA-G 14 bp Indel polymorphism on susceptibility
to HTLV-1 infection in blood donors of Khorasan Razavi
Blood Center
Ganjian Mofrad Z.1, Arab Khazaeli A.2, Mollahoseini F.1,2, Shahabi M.1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Mashhad Blood Transfusion Center, Mashhad, Iran
Abstract
Background and Objectives
The HLA-G antigen is a non-classical HLA class-I with limited polymorphism. Several studies have indicated the role of a 14 bp Indel polymorphism rs371194629 in the 3'-UTR region of the HLA-G in acquisition of HTLV-1 infection. In this study, we investigated the correlation between the genotypes of this polymorphism and HTLV-1 infection in blood donors of Khorasan Razavi province.
Materials and Methods
In this analytical study, a total of 131 healthy individuals and 131 HTLV-1 positive patients were analyzed. After DNA extraction, the genotypes of the polymorphism were determined by PCR-SSP method. Statistical analysis was performed with chi-squared test using SPSS version 23 software.
Results
The DI was the most frequent genotype in both groups (49.6% of controls and 40.3% of patients). The DD genotype was associated with increased risk of HTLV-1 infection (OR=1.89, 95% CI=1.14-3.11, p=0.03). There was no significant difference between the frequency of D and I alleles in both groups.
Conclusions
Our findings confirm previous results about the significance of HLA-G polymorphisms in susceptibility to infectious diseases including HTLV-1. Further investigations could reveal the underlying mechanisms.
Key words: HTLV-1, Infection, HLA-G
Received: 9 Feb 2021
Accepted: 29 Dec 2021
Correspondence: Shahabi M., PhD of Biological Science. Assistant professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88601558; Fax: (+9821) 88601542
E-mail: majshahabi@yahoo.com
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Ganjian Mofrad Z, Arabkhazaeli A, Mollahoseini F, Shahabi M. Role of HLA-G 14 bp Indel polymorphism on susceptibility to HTLV-1 infection in blood donors of Khorasan Razavi Blood Center. Sci J Iran Blood Transfus Organ 2022; 19 (1) :24-29 URL: http://bloodjournal.ir/article-1-1392-en.html
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