[Home ] [Archive]   [ فارسی ]  
:: Main :: About us :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Editorial Board
Advisory Board
Aims & Scope
Journal News
Articles archive::
All Issues
Current Issue
Articles in press
For Authors::
Submission Instruction
For Reviewers::
Reviewers Section
Subscription::
Subscription Form
News& Events::
Journal News
Contact us::
Contact Information
Contact us
Site Facilities::
Site map
Search contents
Top 10 contents
Inform others
Ethics & Permissions::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Indexing
                        
..
:: Volume 18, Issue 2 (Summer 2021) ::
Sci J Iran Blood Transfus Organ 2021, 18(2): 71-78 Back to browse issues page
Evaluation and analysis of quality control results of Fresh Frozen Plasma units in Iranian blood transfusion centers during 1397-1398
M. Abedini , Z. Motamedi , A. Soleimany Ferizhandy , S. Amini Kafi-Abad
Keywords: Fresh Frozen Plasma, WBC, RBC
Full-Text [PDF 397 kb]   (595 Downloads)     |   Abstract (HTML)  (1505 Views)
Type of Study: Research | Subject: Blood Transfusion
Published: 2021/07/1
Full-Text:   (1520 Views)
References:
 
  1. Iranian National Standards for Blood Transfusion. 3rd ed. Tehran: Teimourzadeh Pub; 2016. p. 156. [Persian]
  2. Makris M, van Veen JJ. Three or four factor prothrombin complex concentrate for emergency anticoagulation reversal? Blood Transfus 2011; 9(2): 117-9.
  3. Roback J, Grossman B, Harris T, Hillier C. Technical manual 17th ed. Bethesda, Maryland: AABB. 2011. p. 220.
  4. Council of Europe. European Pharmacopoeia 5.0. 2005; p. 1746.  
  5. Keitel S. Guide to the preparation, use and quality assurance of blood components. France: Council of Europe Publishing; 2017. p. 384.
  6. Pietersz R, De Korte D, Reesink H, Dekker W, Van den Ende A, Loos J. Storage of whole blood for up to 24 hours at ambient temperature prior to component preparation. Vox Sang 1989; 56(3): 145-50.
  7. Omidkhoda A, Tabatabaei MR, Atarodi K, Karimi K, Froushani AR, Pourfathollah AA. A comparative study of the effects of temperature, time and factor VIII assay type on factor VIII activity in cryoprecipitate in Iran. Blood Transfus 2011; 9(4): 394-9.
  8. Omidkhoda A, Nadali F, Babadivand P, Sahlolbeii M, Kafi-Abad SA. The effect of the delayed interval between the separation of plasma and freezing on FVIII activity in FFP. Sci J Iran Blood Transfus Organ 2015; 11(4): 281-5. [Article in Farsi]
  9. Allain J, Friedli H, Morgenthaler JJ, Pflugshaupt R, Gunson H, Lane R, et al. What are the critical factors in the production and quality control of frozen plasma intended for direct transfusion or for fractionation to provide medically needed labile coagulation factors? Vox Sang 1983; 44(4): 246-59.
  10. Myllylä G. Factors determining quality of plasma. Vox Sang 1998; 74(S2): 507-11.
  11. Rock G, Cruickshank W, Tackaberry E, Palmer D. Improved yields of factor VIII from heparinized plasma. Vox Sang 1979; 36(5): 294-300.
  12. Liedén G, Hildén JO. Febrile transfusion reactions reduced by use of buffy-coat-poor erythrocyte concentrates. Vox Sang 1982; 43(5): 263-5.
  13. Rinaldo Jr CR, Black PH, Hirsch MS. Interaction of cytomegalovirus with leukocytes from patients with mononucleosis due to cytomegalovirus. J Infect Dis 1977; 136(5): 667-78.
  14. Mannuccio P, Lattuada A, Ruggeri ZM. Proteolysis of von Willebrand factor in therapeutic plasma concentrates. Blood 1994; 83(10): 3018-27.
  15. Farrugia A, Street A, Douglas S, Raines G, Aumann H, Whyte G, et al. Stablization of von Willebrand factor in banked blood by leucocyte depletion. Transfus Med
    1993; 3(1): 51-7.
  16. Guinet F, Carniel E, Leclercq A. Transfusion-transmitted Yersinia enterocolitica sepsis. Clin Infect Dis 2011; 53(6): 583-91.
  17. Ledent E, Berlin G. Factors influencing white cell removal from red cell concentrates by filtration. Transfusion 1996; 36(8): 714-8.
  18. Willis J, Lown J, Simpson M, Erber W. White cells in fresh-frozen plasma: evaluation of a new white cell-reduction filter. Transfusion 1998; 38(7): 645-9.
  19. Högman C. Preparation and preservation of red cells. Vox Sang 1998; 74(S2): 177-87.
  20. European Committee on Blood Transfusion. Guide to the preparation, use and quality assurance of blood components. France: Council of Europe Publishing; 2020. p. 252.
  21. Sultan S, Zaheer HA, Waheed U, Baig MA, Rehan A, Irfan SM. Internal quality control of blood products: An experience from a tertiary care hospital blood bank from Southern Pakistan. J Lab Physicians 2018; 10(1): 64-7.
  22. Umesh D, Arumugam P. Assessment of the quality of fresh frozen plasma and refrozen thawed fresh frozen plasma–A prospective study at a tertiary care teaching hospital in Chennai. Indian Journal of Pathology and Oncology 2018; 5(2): 286-9.
  23. Gunjan Bala AG, Vijay Suri, Sahil Chhabra, Shaffy, Ramit Gupta. Quality Control of Fresh Frozen Plasma using Factor VIII and Fibrinogen Levels as Measure: One Year Study in a Tertiary Care Hospital. Int J Cont Med Res 2019; 6(8): 28.
  24. Dogra M, Sidhu M, Vasudev R, Dogra A. Comparative analysis of activity of coagulation factors V and VIII and level of fibrinogen in fresh frozen plasma and frozen plasma. Asian J Transfus Sci 2015; 9(1): 6-8.
  25. Grgicević D, Giudici E, Horvat J, Lentz-Catić B, Rudman-Tiska L, Skodlar J, et al. Quality control of frozen plasma in 8 blood transfusion centers in the Croatian Republic. Lijec Vjesn 1992; 114(1-4): 50-2 [Article in Croatian].
  26. Agus N, Yilmaz N, Colak A, Liv F. Levels of factor VIII and factor IX in fresh-frozen plasma produced from whole blood stored at 4 C overnight in Turkey. Blood Transfus 2012; 10(2): 191-3.
  27. Grazzini G, Rossi G, Rafanelli D, Gambelli D, Farina C, Mori F, et al. Quality control of recovered plasma for fractionation: an extensive Italian study. Transfusion 2008;48(7): 1459-68.
  28. Swapnil N Patel  RM, Shah M. Quality control of blood components-a step towards efficient supply of blood products. International Journal of Advanced Research 2016; 4(4): 570-2.
 
 
 
 
 
 
 
 
 
 
 
 
Sci J Iran Blood Transfus Organ 2021;18(2): 71-78
Original Article
 
 
 
 


Evaluation and analysis of quality control results of Fresh Frozen Plasma units in Iranian blood transfusion
centers during 1397-1398
 
Abedini M.1, Motamedi Z.1, Soleimani Ferizhandi A.1, Amini Kafi-Abad S.1
 
 
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
 
 
Abstract
Background and Objectives
Fresh frozen plasma is the plasma that retains its unstable protein activity during the freezing process. The purpose of this study was to investigate the quality of FFP products during 1397- 1398.
 
Materials and Methods
In this cross-sectional descriptive study, quality control results of FFP parameters of blood transfusion departments were collected in EXCEL 2019. The ratio of compliance was investigated using Med Calc Statistical Software and chi squared statistical method. Values of mean ± 1SD, parameters volume, FVIII, WBC, RBC and platelet counts and protein levels were compared by T-test method.
 
Results
In the year 1397, 18744 and in the year 1398, 18282 FFP units were evaluated in terms of quality. The percentage of compliance of FFP quality parameters was increased in 1398 compared to 1397. The differences in the percentage of compliance in FVIII, RBC count and protein parameters were significant (p ≤ 0.05). Mean FVIII increased significantly and the number of  RBC, WBC, and platelets of FFP products in 1398 was significantly decreased compared to 1397 (p ≤ 0.05).
 
Conclusions 
This study showed that more than 99% of the FFP units evaluated during the years 1397-1398 were in accordance with the standards of the Iranian Blood Transfusion Organization. Also, increase in the percentage of compliance with qualitative parameters in 1398, the increase in the average FVIII activity, and the significant decrease in the number of RBC, WBC and platelets of FFP products in 1398 compared to 1397 were indicative of improvement in the production process.
 
Key words: Fresh Frozen Plasma, WBC, RBC
 
 
 
 
Received: 23 Feb 2021
Accepted:  3 Apr 2021
 
 

Correspondence: Amini Kafi-Abad S., MD. Pathologist. Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88601558; Fax: (+9821) 88601542
E-mail: s.amini@ibto.ir
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Abedini M, Motamedi Z, Soleimany Ferizhandy A, Amini Kafi-Abad S. Evaluation and analysis of quality control results of Fresh Frozen Plasma units in Iranian blood transfusion centers during 1397-1398. Sci J Iran Blood Transfus Organ 2021; 18 (2) :71-78
URL: http://bloodjournal.ir/article-1-1384-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 18, Issue 2 (Summer 2021) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4645