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:: Volume 18, Issue 4 (Winter 2021) ::
Sci J Iran Blood Transfus Organ 2021, 18(4): 291-312 Back to browse issues page
A Review of Hemostatic Agents and Products
A. Ansari, F. Khosronezhad, Y. Shallageh, A. Zare, Sh. Afaghi saray, M. Hasanzadeh
Keywords: Key words: Hemostatics, Blood Coagulation Factors, Dressings, Trauma
Full-Text [PDF 739 kb]   (392 Downloads)     |   Abstract (HTML)  (1355 Views)
Type of Study: Review Article | Subject: Hematology
Published: 2021/12/31
Full-Text:   (2847 Views)
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Sci J Iran Blood Transfus Organ 2021;18(4): 291-312
 
Review Article
 
A Review of Hemostatic Agents and Products
 
Ansari A.1,2, KhosronezhadF.2,3, Shallageh Y.1,2, Zare A.2,4, Afaghi Sh.2,5, Hasanzadeh M.6
 
1School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Nanoclub Elites, Tehran, Iran
3Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
4School of Metallurgy and Materials Engineering, University of Tehran, Tehran, Iran
5Faculty of Biomedical Enginnering, Amirkabir University of Technology, Tehran, Iran
6Department of textile engineering, Yazd University, Yazd, Iran
 
Abstract
Background and Objectives
Severe hemorrhage is the leading cause of death in comilitary and civilian trauma. Approximately half of road crash fatalities occur due to severe hemorrhage before hospital arrival. In severe cases of bleeding, the use of agents that accelerate blood coagulation (hemostatic agents) is required. The aim of this study was to review on the hemostatic agents and products, from research to commercial stages, and categorizing them based on the physiology of hemostasis. Moreover, the applications and adverse effects of each category have been reviewed and compared; it can be an important step towards optimal clinical application of products and novel original reasearch design continuing the previous studies.
 
Materials and Methods
Literature search was conducted in scientific databases of PubMed, Scopus, Science Direct, SID, Magiran and IranMedex without filtering release date, by combining related keywords including hemostatic agents, bleeding, dressings and trauma. The abstracts were screened by two reaserchers independently to select the appropriate studies.
 
Results
In this study, according to the basics of blood coagulation, the hemostatic agents and products were classified into five groups based on the mechanism of action including: (1) coagulants and procoagulants, (2) the concentrators of coagvlant factors, (3) mechanical cougulaton substrates, (4) physiologic coagulants and (5) chemical coagulants. The mechanism of action, applications, and side effects have been compared in each category.
 
Conclusions 
Each hemostatic product can be more effective in special situations, in military and civilian trauma, due to their potency and mechanisms of action.
 
Key words: Hemostatics, Blood Coagulation Factors, Dressings, Trauma
 
 
 
 
 
 
 
Received: 15 Dec 2020
Accepted:  6 Oct  2021
 
 

Correspondence: Hasanzadeh M., PhD in Textile Engineering. Assistant Professor of Department of textile engineering, Yazd University.
Postal Code: 8915818411, Yazd, Iran. Tel: (+9835) 31232222; Fax: (+9835) 31232222
E-mail: M.hasanzadeh@yazd.ac.ir
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Ansari A, Khosronezhad F, Shallageh Y, Zare A, Afaghi saray S, Hasanzadeh M. A Review of Hemostatic Agents and Products. Sci J Iran Blood Transfus Organ. 2021; 18 (4) :291-312
URL: http://bloodjournal.ir/article-1-1373-en.html


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