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Sci J Iran Blood Transfus Organ 2020, 17(4): 315-321 Back to browse issues page
A case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K
Vahid Niazi, Massoumeh Shahbazi
Keywords: Key words: Vitamin K, Menorrhagia, Clotting Factor
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Type of Study: case report | Subject: Hematology
Published: 2020/12/30
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Sci J Iran Blood Transfus Organ 2020; 17(4): 315-321
Case  report

A case report of temporary and acquired vitamin
K-dependent clotting factor deficiency without any response
to administrated vitamin K
Niazi V.1, Shahbazi M.2, Moghadasi S.3
1School of Advanced Technologies, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
3School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran
Background and Objectives
Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin.  In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated.
We present a rare case of 43 year woman with acquired vitamin K deficiency and severe menorrhagia without any gynecological problem. The level of all Vitamin-K dependent coagulation factors, Fctor II, Factor VII, Factor IX, and Factor X decreased. Furthermore, even after multiple administration of Vitamin K  and its oral consumption, still the level of coagulation factors and menorrhagia did not ameliorate.
Acquired VKCFD is one of the rare situations that can be life-threatening.
Key words: Vitamin K, Menorrhagia, Clotting Factor
Received:   4 Mar 2020
Accepted: 30 Sep 2020

Correspondence: Niazi V., PhD Student of Applied Cell Sciences. School of Advanced Technologies, Shahid Beheshti University of Medical Sciences.
Postal code: 19857-17443, Tehran, Iran. Tel: (+9821) 22439847; Fax: (+9821) 22439847
E-mail: v_niazi@yahoo.com
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Niazi V, Shahbazi M. A case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K. Sci J Iran Blood Transfus Organ 2020; 17 (4) :315-321
URL: http://bloodjournal.ir/article-1-1337-en.html

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فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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