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:: Volume 17, Issue 4 (Winter 2020) ::
Sci J Iran Blood Transfus Organ 2020, 17(4): 322-335 Back to browse issues page
Identification, Prevention and management of platelet refractoriness
Saeideh Milani , Fatemeh Yari
Keywords: Key words: Platelet Transfusion, Immunoglobulin, Antibodies
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Type of Study: Review Article | Subject: Imunohematology
Published: 2020/12/30
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Sci J Iran Blood Transfus Organ 2020; 17 (4); 322-335
Review  Article


Identification, Prevention and management of platelet refractoriness
Milani S.1, Yari F.1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
Background and Objectives
Platelet refractoriness can be caused by immunological and non-immunological factors. In non-immunological cases, the source which is usually a disease, should be eliminated. In immunological cases antibodies produced against foreign platelet antigens play a significant role. The aim of this review was to investigate the strategies involved in identifying and preventing immunological platelet refractoriness .
Materials and Methods
This article reviews the tests used to identify platelet refractoriness for selection of compatible platelets, as well as prevention and management of the disease. This was done by using keywords; Platelet Transfusion, Platelet Refractory, Corrected Count Increment and Alloantibody and their Persian equivalents through scientific database including  Science Direct, PubMed Medline, SID, Scopus and Magiran, and finally among 100 related articles, 66  were selected.
Since the main immunological cause of platelet refractoriness is production of anti-HLA antibodies, screening for these antibodies is very important. Cross-matching and antibody-specificity prediction can also be performed for these patients. In emergencies, plasma replacement, intravenous immunoglobulin injection, and use of certain medications and compounds could be helpful.
Investigating the efficacy of different methods in diagnosis of platelet refractoriness and detection of compatible platelets has a great impact on prevention, treatment and better management of the disease.
Key words: Platelet Transfusion, Immunoglobulin, Antibodies
Received:  14 Jan 2020
Accepted: 14 Jun 2020

Correspondence: Milani S., PhD of Medical Biotechnology. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
 P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88993778; Fax: (+9821) 88993778
E-mail: s.milani@tmi.ac.ir
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Milani S, Yari F. Identification, Prevention and management of platelet refractoriness. Sci J Iran Blood Transfus Organ 2020; 17 (4) :322-335
URL: http://bloodjournal.ir/article-1-1329-en.html

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فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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