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The prevalence of undesired blood group antibodies in Imam Khomeini Hospital Complex patients
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M.R. Mohamadimaram    , A. Gharehbaghian , A.R. Baghestani , B. Vahidianfar , A.R. Abdollahi , E. Razani , M. Khansari |
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| Keywords: Key words: Blood Group Incompatibility, Alloantibodies, Autoantibodies, Hemolytic Disease of Newborn, Transfusion Reaction |
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Type of Study: Research |
Subject:
Imunohematology
Published: 2019/07/15
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Full-Text: (1766 Views) |
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Sci J Iran Blood Transfus Organ 2019;16(2): 82-90
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The prevalence of undesired blood group antibodies
in Imam Khomeini Hospital Complex patients
Mohammadimaram M.R.1, Gharehbaghian A.1,2, Baghestani A.R.1, Vahidianfar B.3,
Abdollahi A.R.4, Razani E.5, Khansari M.6
1School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
6School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Background and Objectives
There are many antibodies and antigens that cause blood group related transfusion reactions. In this study we aim to find the prevalence of blood group antibodies in patients at different ages and with different gender.
Materials and Methods
In this descriptive study, we screened 30659 patients (59% female and 41% male, age range 1-85) referring to different wards of Imam Khomeini complex hospital during 2017-2018 for presence of any antibodies against blood group antigens. Then, for those patients with screened positive antibody we identified the antibody in each patient. Finally we categorized the antibody positive patients based on their main ABO and Rh blood group of all wards such as cancer, hematology, general and also separately for postpartum ward.
Results
Out of 30659 patients in all wards, 123 and out of 4364 just in postpartum ward, 20 patients had positive antibody. The most prevalent alloantibodies were detected to be anti-E(31.7%), anti-K(30.8%), and anti-D(14.6%) in order.
Conclusions
Anti-E and anti-K are the most likely antibodies presenting in patients with positive antibody screening results awareness of which can be helpful in storing blood components with rare blood groups. Moreover, the evaluation of common alloantibodies in the postpartum ward shows that the administration of RhoGAM might not be adequate in HDFN prevention and other antibodies should be considered in this regard.
Key words: Blood Group Incompatibility, Alloantibodies, Autoantibodies, Hemolytic Disease of Newborn, Transfusion Reaction
Received: 10 Apr 2019
Accepted: 22 May 2019
Correspondence: Mohammadimaram M.R., MSc of Hematology and Blood Banking. School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences.
Postal Code: 8491754683, Tehran, Iran. Tel: (+9831) 52642041; Fax : (+9831) 52642041
E-mail: Mohamadimaram1990@yahoo.com
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Mohamadimaram M, Gharehbaghian A, Baghestani A, Vahidianfar B, Abdollahi A, Razani E et al . The prevalence of undesired blood group antibodies in Imam Khomeini Hospital Complex patients. Sci J Iran Blood Transfus Organ 2019; 16 (2) :82-90 URL: http://bloodjournal.ir/article-1-1262-en.html
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