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:: Volume 14, Issue 1 (Spring 2017) ::
Sci J Iran Blood Transfus Organ 2017, 14(1): 1-7 Back to browse issues page
Increase in Natural auto antibodies against RBCs inhematologic disorders
A.A Pourfathollah Dr., M. Mogadam, S. Goudarzi
Keywords: Key words: Hematologic Diseases, Antibodies, Red Blood Cells
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Type of Study: Research | Subject: Imunohematology
Published: 2017/03/13
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Original  Article
Sci J Iran Blood Transfus Organ 2017; 14(1): 1-7
Increase in Natural auto antibodies against RBCs in
hematologic disorders
Mosaed M.1, Pourfathollah A.A.1,2, Moghadam M.2, Gudarzi S.2
1Faculty of Medical Sciences,Tarbiat Modares University, Tehran, Iran
2Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran 
Background and Objectives
In recent years, Natural auto Abs (NAAbs) are considered as key factors in maintaining the immune homeostasis; NAAbs are also known as biomarkers in various diseases. This research, for the first time, was performed to identify NAAbs that are produced against RBCs following some physiologic changes in patients in comparison to healthy blood donors.    
Materials and Methods
In this fundamental-applied research, two groups of samples including 600 healthy blood donors and 324 patients who have shown pathologic disorders participated. All samples were screened for NAAbs but the identification panel was performed only in the case of positive reaction. Results were analyzed through  binominal test and by SPSS 16.  
NAAbs were detected in 8.6% of healthy population and 17.9% of the patient population, all determined as positive reactions. Only two cases (1 anti-A1 and1 anti-P1) out of 30 were identifiable among the healthy group with auto antibody; however, in the patient group with auto antibody, 19 anti-IH cases, 1 anti-H cases, 2 anti-I cases, 2 anti-P1 cases, and 6 inconclusive cases were identified.
A significant difference between the frequency of NAAbs reactions against RBCs in the two groups was observed (p = 0.03). Furthermore,  anti-IH increases in hematologic diseases.
Key words: Hematologic Diseases, Antibodies, Red Blood Cells
Received: 12 Apr 2016
Accepted:16 Jan 2017

Correspondence: Pourfathollah AA., PhD of Immunology. Professor of Faculty of Medical Sciences of Tarbiat Modares University and Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box:14115-111, Tehran, Iran. Tel: (+9821) 8801101; Fax: (+9821) 88013030
E-mail: pourfa@modares.ac.ir
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Pourfathollah A, Mogadam M, Goudarzi S. Increase in Natural auto antibodies against RBCs inhematologic disorders. Sci J Iran Blood Transfus Organ. 2017; 14 (1) :1-7
URL: http://bloodjournal.ir/article-1-1033-en.html

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