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Increase in Natural auto antibodies against RBCs in
hematologic disorders
 
 
Mosaed M.¹, Pourfathollah A.A.^1,2, Moghadam M.², Gudarzi S.^2
 
 
1Faculty of Medical Sciences,Tarbiat Modares University, Tehran, Iran
²Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran 
 
 
Abstract
Background and Objectives
In recent years, Natural auto Abs (NAAbs) are considered as key factors in maintaining the immune homeostasis; NAAbs are also known as biomarkers in various diseases. This research, for the first time, was performed to identify NAAbs that are produced against RBCs following some physiologic changes in patients in comparison to healthy blood donors.    
 
Materials and Methods

Results
NAAbs were detected in 8.6% of healthy population and 17.9% of the patient population, all determined as positive reactions. Only two cases (1 anti-A1 and1 anti-P1) out of 30 were identifiable among the healthy group with auto antibody; however, in the patient group with auto antibody, 19 anti-IH cases, 1 anti-H cases, 2 anti-I cases, 2 anti-P1 cases, and 6 inconclusive cases were identified.
 
Conclusions
A significant difference between the frequency of NAAbs reactions against RBCs in the two groups was observed (p = 0.03). Furthermore,  anti-IH increases in hematologic diseases.
 
Key words: Hematologic Diseases, Antibodies, Red Blood Cells
 
 
 
 
 
 
 
 
 
Received: 12 Apr 2016
Accepted:16 Jan 2017
 
 
 

Correspondence: Pourfathollah AA., PhD of Immunology. Professor of Faculty of Medical Sciences of Tarbiat Modares University and Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box:14115-111, Tehran, Iran. Tel: (+9821) 8801101; Fax: (+9821) 88013030
E-mail: pourfa@modares.ac.ir