|
The genetic diversity of the HLA-B*35 and HLA-B*51 allele groups among ethnicities in Iran
|
F. Yari    , A. Teimourpour , M. Zaman Vaziri , F. Sabaghi , N. Bagheri , F. Mortezapour |
|
|
|
Abstract: (125 Views) |
Abstract
Background and Objectives
Comparing the genetic diversity of HLA molecules among various ethnic groups in Iran can assist in providing suitable strategies for sourcing hematopoietic stem cell donors for Iranian patients. The objective was to compare two prevalent allelic groups in the overall population of Iran, specifically HLA-B*35 and HLA-B*51, across different Iranian ethnicities.
Materials and Methods
In this descriptive study, the determination of HLA-B alleles was conducted at low resolution level using the PCR-SSP method. Ethnic data and HLA information were collected and analyzed from the Arab ethnicity (n=370) as well as the Gilak (n=510), Lur (n=465), and Kurdish (n=719) ethnic groups. The relationship between alleles and ethnicity was examined, and a chi-square statistical method was employed to assess the significant relationship between the allele frequencies.
Results
The Frequencies of HLA-B*35 among the Lur, Gilak, Arab, and Kurdish populations were recorded as follows: 20.22%, 22.75%, 11.35%, and 19.61%, respectively. Similarly, the prevalence of HLA-B*51 was noted as 18.28%, 9.31%, 9.32%, and 17.52%. The overall frequencies observed in the general population of Iran in this study were 19% for HLA-B*35 and 14.2% for HLA-B*51. Furthermore, the frequencies for the two mentioned allelic groups in the studied ethnicities showed significant differences (P<0.05).
Conclusions
Although HLA-B*35 and HLA-B*51 exhibited the highest frequencies at the HLA-B gene locus in the overall population and the ethnic groups, the differences in the frequencies among the ethnicities were significant. This study highlights the high genetic diversity of HLA-B within the studied ethnic groups.
|
|
| Keywords: Key words: ethnicity, Iran, HLA-B51, HLA-B35 |
|
|
Full-Text [PDF 400 kb]
(79 Downloads)
| | Full-Text (HTML) (45 Views)
|
Type of Study: Research |
Subject:
Imunology
Published: 2024/10/1
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
.jpg)
.png)
