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:: Volume 4, Issue 4 (winter 2008) ::
Sci J Iran Blood Transfus Organ 2008, 4(4): 259-264 Back to browse issues page
Correlation between plasma total homocysteine concentration and the risk of thrombosis
M.R. Deyhim , F. Razjou, M. Maghsudlu, M. Abedini
Abstract:   (23937 Views)

  Abstract

 Background and Objectives

 Venous thrombosis is one of the important causes of morbidity and mortality all over the world. Elevated plasma homocysteine is known as a cause of vein morphology changes and endothelial dysfunction which lead to platelet activation, fibrinolysis inhibition and finally atherothrombosis. In this study, we evaluated the role of homocysteine in atherothrombosis as compared to the control group with no history of thrombosis.

 

 Materials and Methods

 In this case control study‚ 100 patients with arterial thrombosis (54 men and 46 women) as the case group and 68 as control (40 men and 28 women) were involved. Blood samples were taken in the EDTA-located tube and transported to the laboratory for fasting plasma homocysteine to be measured by ELISA kits. Some data such as age, sex, thrombosis history, and familial thrombosis history were taken from the patients through a questionnaire. We measured fasting plasma homocysteine in both case and control groups by ELISA method. The statistical analysis was performed by SPSS statistical software using T-Test and Chi-square odds ratio was also calculated.

 

 Results

 The average rates of homocysteine in the case and control group were 23.85 ± 18.4 and 11.48 ± 3.4 µmol/lit respectively showing statistical significance. The hyperhomocysteinemia frequency in the case group was 48%, whereas 17.6% in the control. A significant difference was also observed in the frequency of hyperhomocysteinemia between male (70.4%) and female (21.7%) in the case group. There was a moderate correlation between homocysteine level and age in the case group.

 

 Conclusions

 According to the achieved odds ratio (2.72), hyperhomocysteinemia is an independent risk factor for thrombosis. It means that homocysteine measurement should be determined in thrombosis-affected or high risk patients. Dietary supplementation with low doses of folate and vitamin B12 should be considered in affected persons.

 

 Key words : Homocysteine, Venous thrombosis, Risk factor

Keywords: Homocysteine, Venous thrombosis, Risk factor
Full-Text [PDF 216 kb]   (3205 Downloads)    
Type of Study: Research | Subject: Hematology
Published: 2014/08/17
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Deyhim M, Razjou F, Maghsudlu M, Abedini M. Correlation between plasma total homocysteine concentration and the risk of thrombosis. Sci J Iran Blood Transfus Organ. 2008; 4 (4) :259-264
URL: http://bloodjournal.ir/article-1-191-en.html


Volume 4, Issue 4 (winter 2008) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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