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Red blood cells storage lesion: the effect of blood donation time on biochemical parameters
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ُS. Jahanshahi Ghajar   , M.R. Deyhim  , F. Sotoudehnejad Nematollahi , M.H. Rafiee |
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| Keywords: Key words: Blood Donation, Blood Banking, Circadian Rhythm |
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Type of Study: Research |
Subject:
Biochemistry
Published: 2019/10/2
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Full-Text: (1833 Views) |
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Sci J Iran Blood Transfus Organ 2019;16 (3): 161-171
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Red blood cells storage lesion: the effect of blood
donation time on biochemical parameters
Jahanshahi Ghajar S.1, Deyhim M.R.2, Sotoudehnejad Nematollahi F.3, Rafiei M.H.2
1Science and Research Branch, Islamic Azad University, Tehran, Iran
2Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
3Faculty of Basic Sciences, Islamic Azad University, Tehran, Iran
Abstract
Background and Objectives
There is a circadian rhythm and diurnal variation in the redox capacity in blood plasma and there is a decrease in antioxidant capacity (TAC) during the RBCs storage in blood banking. So it is possible that donated blood, based on donation time, has a different antioxidant capacity and as a result a different biochemical response during storage. This study attempts to uncover this issue.
Materials and Methods
In this experimental study, Twenty RBC units were collected from two donor groups in the morning (8-11am) and evening (5-8pm) and were stored for 3 to 42 days at 4 to 8 degrees Celsius. Glucose, Sodium, potassium, lactate, lactate dehydrogenase (LDH), pH, malondialdehyde (MDA), and total antioxidant capacity were measured by a commercial kit. Nitrate/nitrite was measured by Griess method.
Results
The levels of nitrate/nitrite, MDA, and LDH in the evening group increased significantly when compared to the morning group (p < 0.05). However, a decreasing trend in TAC, pH, Glucose, and sodium levels (p < 0.05) versus an increasing trend in potassium, lactate, LDH, and MDA was seen in both groups during storage (p < 0.05).
Conclusions
This study showed that oxidative damage in donated blood in the evening was higher than in the morning during storage, which may reduce RBC survival. Therefore, more studies are required with more sample sizes to examine the effect of donation time on the RBC storage lesion.
Key words: Blood Donation, Blood Banking, Circadian Rhythm
Received: 31 Dec 2018
Accepted: 2 Jun 2019
Correspondence: Rafiei MH., PhD in Clinical Biochemistry. Assistant Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine .
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 82052230; Fax: (+9821) 88601555
E-mail: hessam.rafiee@yahoo.com |
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Jahanshahi Ghajar ُ, Deyhim M, Sotoudehnejad Nematollahi F, Rafiee M. Red blood cells storage lesion: the effect of blood donation time on biochemical parameters. Sci J Iran Blood Transfus Organ 2019; 16 (3) :161-171 URL: http://bloodjournal.ir/article-1-1243-en.html
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