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:: Volume 15, Issue 4 (Winter 2018) ::
Sci J Iran Blood Transfus Organ 2018, 15(4): 272-286 Back to browse issues page
Effect of synthetic biologically activated 45S5 glass nanoparticles on osteogenesis differentiation of mesenchymal human bone marrow
M. Shamsi , A. Salimi , M. Ghallasi , R. Halabian
Department of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran.
Keywords: Key words: Nanoparticles, Mesenchymal Stem Cells, Glass
Full-Text [PDF 929 kb]   (2172 Downloads)     |   Abstract (HTML)  (3518 Views)
Type of Study: Research | Subject: Stem cells
Published: 2019/01/5
Full-Text:   (3526 Views)
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Sci J Iran Blood Transfus Organ 2019; 15(4): 272-286
Original Article
 

 

Effect of synthetic biologically activated 45S5 glass nanoparticles on osteogenesis differentiation
of mesenchymal human bone marrow
 
Shams M.1, Salimi A.2, Ghollasi M.3, Halabian R.4
 
 
1Institute of Materials and Energy(MERC), Karaj, Iran
2Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
3Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
4Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
 
 
Abstract
Background and Objectives
Glasses and glass-ceramics are a group of biological substances that form hydroxyapatite against a simulated solution of the body and can be used in many clinical cases that require the production and repair of bone. The purpose of this study was to create a 45S5 bioactive glass nanoparticle and evaluate its impact on staining and differentiation of mesenchymal stem cells into bone cells.
 
Materials and Methods
In this experimental research, the nanocomposite of the bioaccuminant 45S5 was synthesized by the fusion method and planetary mill was converted to the nanoscale structure; then, its physicochemical and structural properties were investigated. The bioactivity was evaluated using a simulated body solution. The growth, amplification and differentiation of mesenchymal stem cells in the vicinity of nanoparticles were investigated.
 
Results
Biomedical evaluation indicated the formation of hydroxyapatite on nanoparticles after zinc immersion in the body was simulated. Cell experiments also confirmed the lack of toxicity of the glass nanoparticles and its stimulating effect for the growth, proliferation and differentiation of mesenchymal cells in bone cells. In the bone differentiation, the activity of alkaline phosphatase in the glass nanoparticle was expressed after 14 days of differentiation (0.55 ± 0.07), while it was the control sample (0.15 ± 0.03).
 
Conclusions 
According to the progenies, mesenchymal stem cells can propagate and grow on the nanoparticles of the synthesized bioactive glass and, in addition to not being toxic, stimulate and stimulate cell growth.
 
Key words: Nanoparticles, Mesenchymal Stem Cells, Glass
 
 
Received:  4 Jul  2018
Accepted: 2 Sep 2018
 
 

Correspondence: Halabian R., PhD in Medical Biotechnology. Assistant professor of Faculty of Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sieances.
P.O.Box: 14359-44711, Tehran, Iran. Tel: (+9821) 86072709 ; Fax: (+9821) 86072709
E-mail:
r.halabian@yahoo.com
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Shamsi M, Salimi A, Ghallasi M, Halabian R. Effect of synthetic biologically activated 45S5 glass nanoparticles on osteogenesis differentiation of mesenchymal human bone marrow. Sci J Iran Blood Transfus Organ 2018; 15 (4) :272-286
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Volume 15, Issue 4 (Winter 2018) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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