High prevalence of parvovirus B19 IgG antibody among hemophilia patients attending Shiraz Center for Special Diseases
|
M. Mahmoodian Shooshtari , M.N. Forughi , R. Hamkar |
|
|
Abstract: (18757 Views) |
Abstract Background and Objectives Human Parvovirus B19, the causative agent of fifth disease in childhood, lacks lipid envelop and is resistant to many physicochemical agents. B19 is a potential risk to hemophiliac patients receiving blood products. Materials and Methods The present research is a descriptive and cross-sectional study. To determine the prevalence of the corresponding antibody in patients with hemophilia A or B or Von Willbrand’s disease, we tested 180 hemophilia patients for anti B19 IgG. The results were compared with those of 400 age-matched controls subjects (male blood donors and children). SPSS version 10 and Chi-squar were used for data analysis. Results The overall prevalence of B19 IgG in the hemophilia patients was 74% (133/180) and in the control 56.5% (226/400, p<0.001). Conclusions These observations demonstrate that parvovirus B19 is frequently transmitted by blood products. Existing virus-inactivating methods do not prevent transmission. Key words: Parvovirus B19, Hemophilia, Viral inactivation, Plasma product |
|
Keywords: Parvovirus B19, Hemophilia, Viral inactivation, Plasma product |
|
Full-Text [PDF 197 kb]
(2421 Downloads)
|
Type of Study: Research |
Subject:
General Published: 2014/06/30
|
|
|
|