|
Determination of the Effect of Autologous Platelet Gel on Cutaneous Leishmaniasis Wounds Healing
|
E. Shadmand    , K. Solhjo , A. Hashemi tayer |
|
|
| Keywords: Key words: Platelets, Growth Factors, Leishmaniasis, Wound Healing |
|
|
Full-Text [PDF 438 kb]
(1010 Downloads)
| Abstract (HTML) (3045 Views)
|
Type of Study: Research |
Subject:
Blood transfusion medicine
Published: 2019/07/15
|
|
|
|
|
|
|
Full-Text: (1718 Views) |
References:
- Cardo LJ, Rentas FJ, Ketchum L, Salata J, Harman R, Melvin W, et al. Pathogen inactivation of leishmania donovani infantum in plasma and platelet concentrates using riboflavin and ultraviolet light. Vox Sang 2006; 90(2): 85-91.
- Davami MH, Motazedian MH, Sarkari B. The changing profile of cutaneous leishmaniasis in a focus of the disease in Jahrom district, southern Iran. Ann Trop Med Parasitol 2014; 104(5): 377-382.
- Aronson N, Herwaldt BL, Libman M, Pearson R, Lopez-Velez R, Weina P, et al. Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Am J Trop Med Hyg 2017; 96(1): 24-45.
- Kazakos K, Lyras DN, Verttas D, Tilkeridis K, Tryfonidis M. The use of autologus PRP gel as an aid in the management of acute trauma wounds. Injury 2009; 40(8):801-805.
- Yamakawa S, Hayashida K. Advances in surgical applications of growth factors for wound healing. Burns Trauma 2019; 7: 10.
- Skwarcz S, Bryzek I, Gregosiewicz A, Warda E, Gawęda K, Tarczyńska M, et al. Autologous activated platelet-rich plasma (PRP) in bone tissue healing - does it work? Assessment of PRP effect on bone defect healing in animal models. Pol J Vet Sci 2019; 22(1): 109-115.
- Burnouf T, Chou ML, Wu YW, Su CY, Lee LW. Antimicrobial activity of platelet (PLT)-poor plasma, PLT-rich plasma, PLT gel, and solvent/detergent-treated PLT lysate biomaterials against wound bacteria. Transfusion 2013; 53(1):138-146.
- Martinez-Zapata MJ, Martí-Carvajal AJ, Solà I, Expósito JA, Bolíbar I, Rodríguez L, et al. Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database Syst Rev 2016; 25(5): CD006899.
- Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2001; 91(1): 4-15.
- Heidari-Bateni M, Alizadeh Sh, Hashemi-Tayer A, Almasi-Hashiani A. The effect of autologus platelet glue on healing burn wounds: An in vivo study. Arak Medical University Journal 2013; 16(72): 12-19.
- Kargar S, Javadzadeh Shahshahani H, Tabkhi N. The effect of platelet gel on treatment of diabetic foot ulcer. Sci J Iran Blood Transfus Org 2010; 6(4): 283-292.
- O'Meara SM, Cullum NA, Majid M, Sheldon TA. Systematic review of antimicrobial agents used for chronic wounds. British Journal of Surgery 2001; 88(1): 4-21.
- Hashemi Tayer A, Alizadeh Sh, Heidari Bateni M. Efficacy of a new autologus platelet gel; in vitro study. Iran J Ped Hematol Oncol 2012; 2(2): 54-59.
- Wu PI, Diaz R, Borg-Stein J. Platelet-Rich Plasma. Phys Med Rehabil Clin N Am. 2016; 27(4): 825-853.
- Martineu I, Lacoste E, Gagnon G. Effect of calcium and thrombin on growth factor release from platelet concentrates: Kinetic and regulation of endothelial cell proliferation. Biomaterial 2004; 25(18): 4489-502.
- Sommeling CE, Heyneman A, Hoeksema H, Verbelen J, Stillaert FB, Monstrey S. The use of platelet-rich plasma in plastic surgery: a systematic review. J Plast Reconstr Aesthet Surg 2013; 66(3): 301-311.
- Hom DB, Linzie BM, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg 2007; 9; 174-183.
- Loquercio G, Costanzo GI, Fazioli F, Gallo M, Chiara AD, Iervolino V, et al. Autologous platelet gel improves bone reconstruction of large defects in patients with bone giant cell tumors. In Vivo 2015; 29(5): 533-540.
- Goda AA, Metwally M, Ewada A, Ewees H. Platelet-rich plasma for the treatment of diabetic foot ulcer: a randomized, double-blind study. Egypt J Surg 2018; 37:178-184.
- Piccin A, Di Pierro AM, Canzian L, Primerano M, Corvetta D, Negri G, et al. Platelet gel: a new therapeutic tool with great potential. Blood Transfus 2017;15(4):333–340.
- Zimmermann R, Arnold D, strasser E, et al: sample preparation technique and white cell content influence the detectable levels of growth factors in platelet concentrates. Vox Sang 2003, 85: 283-9.
- Badade Pallavi S, Mahale Swapna A, Panjwani Alisha A, Vaidya Prutha D, Warang Ayushya D. Antimicrobial effect of platelet-rich plasma and platelet-rich fibrin. Indian Journal of Dental Research 2016; 27(3): 300-304.
|
Sci J Iran Blood Transfus Organ 2019;16(2): 116-123
|
Determination of the Effect of Autologous Platelet
Gel on Cutaneous Leishmaniasis Wounds Healing
Shadmand E.1, Solhjoo K.1, Hashemi Tayer A.1
1School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
Abstract
Background and Objectives
Platelet Gel (PG) is rich in growth factors with healing properties and is used in most surgeries to treat various types of tissue defects. In this study, the effect of autologous platelet gel (APG) was evaluated on healing of cutaneous leishmaniasis wounds.
Materials and Methods
This randomized clinical trial was done on 15 patients with cutaneous leishmaniasis; the follow-up assessment lenghthened for two months. The patients had more than one cutaneous ulcer with one of the wounds evaluated as the control and the other as the intervention group. The control group was treated with glucantime routine treatment and the intervention group received a platelet gel in addition to routine treatment. PG was used once a week and up to 7 times in the wound site. Granulation tissue formation and epithelialization were the tokens of wound recovery and positive response to treatment.
Results
The use of APG in the intervention group was associated with a complete and faster wound healing in 66% of the cases and 34% of the wounds had a relative improvement. During the two months of assessment, none of the wounds of the control group was associated with complete recovery. In the intervention group, the mean area of the wound was 160.6 ± 148.9 mm2 in the first week and changed to 86.9 ± 121.6 mm2 in the eighth week with descending change being statistically significant (p < 0.001).
Conclusions
Platelet gel can be effective in wound healing and scar removal in the wounds caused by cutaneous leishmaniasis.
Key words: Platelets, Growth Factors, Leishmaniasis, Wound Healing
Received: 20 Apr 2019
Accepted: 2 Jun 2019
Correspondence: Hashemi Tayer A., PhD of Hematology. Assistant Professor of School of Medicine, Jahrom University of Medical Sciences.
Postal Code: 74148046199, Jahrom, Iran. Tel: (+9871) 54340405; Fax : (+9871) 54340823
E-mail: a.hashemi@jums.ac.ir
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Shadmand E, Solhjo K, hashemi tayer A. Determination of the Effect of Autologous Platelet Gel on Cutaneous Leishmaniasis Wounds Healing. Sci J Iran Blood Transfus Organ 2019; 16 (2) :116-123 URL: http://bloodjournal.ir/article-1-1264-en.html
|
.jpg)
.png)
