جلد 22، شماره 2 - ( تابستان 1404 )                   جلد 22 شماره 2 صفحات 149-137 | برگشت به فهرست نسخه ها

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Nakhaei Shamahmood M, Nasiri M, Meghdadi M, Mortazi H, Asadifard M, Erfani F, et al . Kell and E Alloantibodies as the Main Causes of Alloimmunization in Transfusion-Dependent Thalassemia Patients: A Cross-Sectional Study. Journal of Iranian Blood Transfusion 2025; 22 (2) :137-149
URL: http://bloodjournal.ir/article-1-1586-fa.html
نخعی شامحمود مبینا، نصیری مازیار، مقدادی محمدرضا، مرتاضی حسن، اسدی فرد معصومه، عرفانی فرزانه، و همکاران.. آلوآنتی بادی‌های Kell و E، علل اساسی آلوایمونیزاسیون در بیماران تالاسمی وابسته به تزریق خون: مطالعه مقطعی. فصلنامه پژوهشی خون. 1404; 22 (2) :137-149

URL: http://bloodjournal.ir/article-1-1586-fa.html


استادیار مرکز تحقیقات سلولی و مولکولی ـ دانشکده پیراپزشکی دانشگاه علوم پزشکی بیرجند
چکیده:   (147 مشاهده)
چکیده
سابقه و هدف 
بیماران مبتلا به تالاسمی ماژور نیازمند به تزریق خون منظم می‌باشند و یکی از مهم‎ترین عوارض انتقال مکرر خون در آن‌ها، تولید آلوآنتی‌بادی است. این مطالعه با هدف بررسی فراوانی و نوع آلوآنتی‌بادی‌های شایع در بیماران مبتلا به تالاسمی انجام شد. 
مواد و روش‌ها
مطالعه توصیفی - مقطعی حاضر بر روی 45 بیمار مبتلا به تالاسمی ماژور وابسته به تزریق خون شهرستان بیرجند در سال 1403 انجام شد. آزمایش غربالگری آنتی‌بادی‌ انجام و سپس هویت آنتی‌بادی‌ها تعیین شد. هم‌چنین موارد مربوط به سن، جنس و اطلاعات بالینی و آزمایشگاهی بیماران تالاسمی از پرونده الکترونیک آن‌ها استخراج گردید. داده‌های به دست آمده با استفاده از نر‌م‌افزار SPSS نسخه 26 مورد تجزیه و تحلیل قرار گرفت و از آزمون‌های آماری کای‌دو و دقیق فیشر برای ارتباط بین متغیرها با یکدیگر استفاده شد.
یافته‌ها
در این مطالعه تعداد 45 بیمار شامل 21 مرد (46/6%) و 24 زن (53/3%)، با دامنه سنی 36-1 سال مورد مطالعه قرار گرفتند. شیوع آلوآنتی‌بادی در بیماران تالاسمی وابسته به تزریق خون با فاصله اطمینان 95% برابر با ۲/۲ تا 1/18 درصد بود. 4 آلوآنتی‌بادی شناسایی شد که شایع‌ترین آلوآنتی‌بادی‌‌ها شامل anti-K (3 نفر، 100%) و anti-E (1 نفر، 33%) بود. فراوان‌ترین فنوتیپ سیستم ABO، گروه خونی O (42/2%) و فراوان‌ترین آنتی‌ژن سیستم Rh، آنتی‌ژن c وe  بود که بـه ترتیب در100% و 93/3 % بیماران وجود داشت. 7 بیمار (15/5%) تحت عمل طحال‌برداری قرار گرفته بودند. ارتباط معنا‌داری بین آلوایمونیزاسیون با گروه سنی، جنس، گروه خونی، تعداد واحدهای خون تزریق‌ شده و وضعیت طحال‌ مشاهده نشد. 
نتیجه گیری            
با توجه به شناسایی آلوآنتی‌بادی‌ها علیه سیستم‌های گروه خونی Kell و Rh (E) ، در جامعه تالاسمی مورد مطالعه بایستی از خـونی استفاده شود که حداقل از نظر آنتی‌ژن‌های سیستم‌های گروه‌های خونی Kell و Rh با خون بیمار تطابق داشته باشد.
 
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نوع مطالعه: پژوهشي | موضوع مقاله: تالاسمي

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