2024-03-29T09:13:20+03:30 http://bloodjournal.ir/browse.php?mag_id=79&slc_lang=fa&sid=1
79-1385 2024-03-29 10.1002
Scientific Journal of Iran Blood Transfus Organ Sci J Iran Blood Transfus Organ 1027-9520 1735-8248 2022 19 1 Frequency of the Order and Consumption Rates of Blood Components at Emam Sajjad Hospital in Ramsar, 2018-2019 Sh. Keyhanian S. Mostafazadeh s.mostafazadeh@live.com Abstract Background and Objectives Blood products are important to many patients. Due to excessive demand for blood, which causes blood loss and increases the cost of treatment and the workload of the blood bank, it is necessary to consider the demand and consumption rates of blood products. Materials and Methods In this descriptive study, blood request forms were examined for individuals over 18 years of age referred to Imam Sajjad Hospital in Ramsar from January 2019 to January 2020. Data were analyzed by SPSS software version 25 and Chi-square Test. Descriptive statistics (frequency, percentage, and mean) and blood transfusion indices including cross-matched to injected blood ratio (C/T), blood transfusion index (TI), and blood transfusion probability (T%) were calculated. Results 3111 blood request forms were reviewed. Out of 7640 units of requested blood, 5051 units (66.11%) were injected into patients. Among the hospital sectors, gynecology department with 58 units (1.1%) had the lowest frequency of consumption of packed RBCs. The overall C⁄T ratio was calculated to be 1.56. Overall TI was 1.22 and TÙªwas 65.82%. Conclusions  This study showed that the ratio of transfusion indices was appropriate for all departments of Imam Sajjad Hospital in Ramsar except for gynecology. Due to the high demand for blood compared to consumption, unnecessary requests can be significantly reduced by properly examining patients and applying the principles of blood ordering.   Key words: Red Blood Cells Blood Transfusion Hospitals 2022 3 01 1 9 http://bloodjournal.ir/article-1-1385-en.pdf
79-1419 2024-03-29 10.1002
Scientific Journal of Iran Blood Transfus Organ Sci J Iran Blood Transfus Organ 1027-9520 1735-8248 2022 19 1 Identification and risk assessment in the process of blood donation in a fixed blood collection center of Saqez city by Failure Mode and Effects Analysis S. Mohammadi M.S. Karimian S. Khodakarimi sk3005i@yahoo.com S. babahajiyani A. Pourali S. Vafaei seyvanvafaii@yahoo.com Abstract Background and Objectives Risk is a combination of the likelihood of an incident occurring and the severity of the consequences if that incident were to occur. The aim of this research is to identify and evaluate the risk factors in the blood donation process in a fixed blood collection center of Saqez city by failure mode and effects analysis (FMEA). Materials and Methods It is a descriptive-applied study that was performed in a fixed blood collection center of Saqez in 2020. The researcher collected and analyzed the data using FMEA worksheets. Then the risk priority number is obtained by multiplying the three indicators of failure severity (S), the failure probability of occurrence (O), and the failure detection (D). Finally, the priority was based on the failures. Results Finally, 30 sub-processes were identified, of which 20 sub-processes with acceptable risk and 10 sub-processes with unacceptable risk were identified. The highest identified risk is related to the donor not paying attention to safety points before and after blood donation with a priority risk number of 168 and the lowest is attributed to the shaker not alarmed when the blood donation process ends with a RPN of 48. Conclusions  Many of the failures identified will be reduced or eliminated by training, providing up-to-date equipment, and changing procedures and working methods.   Risk Risk Assessment Blood Donors Blood Donation 2022 3 01 10 23 http://bloodjournal.ir/article-1-1419-en.pdf
79-1392 2024-03-29 10.1002
Scientific Journal of Iran Blood Transfus Organ Sci J Iran Blood Transfus Organ 1027-9520 1735-8248 2022 19 1 Role of HLA-G 14 bp Indel polymorphism on susceptibility to HTLV-1 infection in blood donors of Khorasan Razavi Blood Center Z. Ganjian Mofrad A. Arabkhazaeli F. Mollahoseini M. Shahabi majshahabi@yahoo.com Abstract Background and Objectives The HLA-G antigen is a non-classical HLA class-I with limited polymorphism. Several studies have indicated the role of a 14 bp Indel polymorphism rs371194629 in the 3'-UTR region of the HLA-G in acquisition of HTLV-1 infection. In this study, we investigated the correlation between the genotypes of this polymorphism and HTLV-1 infection in blood donors of Khorasan Razavi province. Materials and Methods In this analytical study, a total of 131 healthy individuals and 131 HTLV-1 positive patients were analyzed. After DNA extraction, the genotypes of the polymorphism were determined by PCR-SSP method. Statistical analysis was performed with chi-squared test using SPSS version 23 software. Results The DI was the most frequent genotype in both groups (49.6% of controls and 40.3% of patients). The DD genotype was associated with increased risk of HTLV-1 infection (OR=1.89, 95% CI=1.14-3.11, p=0.03). There was no significant difference between the frequency of D and I alleles in both groups. Conclusions  Our findings confirm previous results about the significance of HLA-G polymorphisms in susceptibility to infectious diseases including HTLV-1. Further investigations could reveal the underlying mechanisms. HTLV-1 Infection HLA-G 2022 3 01 24 29 http://bloodjournal.ir/article-1-1392-en.pdf
79-1438 2024-03-29 10.1002
Scientific Journal of Iran Blood Transfus Organ Sci J Iran Blood Transfus Organ 1027-9520 1735-8248 2022 19 1 Identify and present a model of individual factors affecting the development of organizational citizenship behavior(Case Study: Central Headquarters of the Blood Transfusion Organization of Iran) A. Safarifard H. Amiri hassanamiri1349@yahoo.com K. Parsa Moein B. Alishiri Abstract Background and Objectives Rapid change, serious competition, and the need to increase productivity have made organizations need employees to go beyond their job responsibilities, which is called "Organizational Citizenship Behavior (OCB)". One of the effective factors in the development of these behaviors is individual factors. The present study was conducted to identify these factors in the headquarters of Iranian Blood Transfusion Organization. Materials and Methods This research has an applied approach that was conducted in two parts: qualitative and quantitative. In the qualitative section, 13 experts and specialists were selected by a completely purposeful method and thus the statistical population of the study was formed. MAXQDA-2020 software was used to analyze the data. In the quantitative part of the statistical population of the study, the staff of the central headquarters of IBTO consisted of 210 people who were sampled by simple random sampling method. Results Regarding individual factors, the results showed that the personality (factor loading 0.94), job satisfaction (0.93), work conscience (0.87), organizational commitment (0.84), motivation (0.77), and communication skills (0.71) were effective in developing organizational citizenship behavior. The results of the first and second order confirmatory factor analysis of the individual factors model indicate the appropriateness of the measurement model of the relevant variables. Conclusions  It is suggested that in order to develop OCB, managers of IBTO should pay attention to the factors identified in the research and hold training courses focusing on recognizing the status and importance of these behaviors to achieve the goals of the organization.   Key words: Citizenship Behavior Development Blood Transfusion Organizations 2022 3 01 30 43 http://bloodjournal.ir/article-1-1438-en.pdf
79-1425 2024-03-29 10.1002
Scientific Journal of Iran Blood Transfus Organ Sci J Iran Blood Transfus Organ 1027-9520 1735-8248 2022 19 1 Evaluation of complications of ABO incompatibility following blood transfusion in 2019 L. Kasraian Z. Afsar B. Shirazi babakshirazi@yahoo.com M. Farahangiz N. Naderi nima_naderi54@yahoo.com Abstract Background and Objectives One of the dangers of blood transfusions is the mistakes that lead to the wrong blood transfusion to the patient. This study was performed to identify the types of errors that lead to incompatible transfusions to prevent their recurrence and increase recipients health. Materials and Methods This cross-sectional study was performed on complications of ABO incompatibility caused by transfusion in 2019 in Shiraz hospitals. Demographic characteristics of blood recipients (age, sex, diagnosis, history of transfusion, blood type), type of product received, blood type of product received, incompatible blood volume injected, symptoms and causes of ABO incompatibility were determined. Chi-square and t-test were used to analyze data. Results A total of 9 complications of ABO incompatibility were reported; 7 cases (77.8%) were due to packed red blood cells, one case (11.1%) due to platelet injection and one (11.1%) due to plasma injection. Seven cases occurred in patients undergoing surgery, one case in neonates and one in thalassemia patients. In terms of clinical symptoms, only one patient developed chills. The rest of the patients had no symptoms. The most common error leading to inconsistency was the lack of accurate identification in 6 cases (66.7%) and in 2 cases (22.2%) sampling error and in one (11.1%) incorrect group writing. Conclusions  It seems that in order to promote safe blood transfusion, it is important to investigate the occurrence of ABO incompatibilities in order to identify blood transfusion chain errors in order to identify the causes of errors and prevent the recurrence of these complications. ABO Blood-Group System Blood Transfusion Complications 2022 3 01 44 51 http://bloodjournal.ir/article-1-1425-en.pdf
79-1417 2024-03-29 10.1002
Scientific Journal of Iran Blood Transfus Organ Sci J Iran Blood Transfus Organ 1027-9520 1735-8248 2022 19 1 Study of the process of maintaining medical equipment in Iranian blood centers M. Fallah Tafti m.falah@ibto.ir K. Mosavi Hosseini R. Golestani Shishvan Abstract Background and Objectives Preventive maintenance plays a crucial role in ensuring continuous operation and increasing the accuracy and safety of medical equipment. The existence of this system can significantly reduce the cost of the repair and replacement. In this study, the effectiveness of the maintenance of medical equipment of 7 blood centers was evaluated in Tehran, Karaj, Gilan, Mazandaran, Semnan, Shiraz and Yazd during the years 2016-2018. Materials and Methods In this cross-sectional study, the effectiveness of establishing maintenance management on 201 devices with a history of more than 5 years in 7 blood transfusion centers was evaluated. Performance status and effectiveness of periodic visits and training were done through a questionnaire and in person. Descriptive and inferential statistics, one-way analysis of variance, and Spearman correlation coefficient were used to analyze the data. The results were statistically calculated using SPSS 16 software. Results The results of this study showed that about 40% of the medical equipment of these centers do not have a regular evaluation and the operating conditions of the devices, periodic visits and user training were 87%, 64% and 43% in good scale, respectively. Analysis of variance also showed that the mean scores of equipment performance conditions, periodic visits, and user training were not statistically significant according to relevant international standards. Conclusions  Establishment of medical equipment maintenance management has led to continued performance, increased accuracy of results, access time, and useful life along with reduced breakdowns and the cost of repairs.   Key words: Equipment Maintenance Blood Transfusion 2022 3 01 52 60 http://bloodjournal.ir/article-1-1417-en.pdf
79-1410 2024-03-29 10.1002
Scientific Journal of Iran Blood Transfus Organ Sci J Iran Blood Transfus Organ 1027-9520 1735-8248 2022 19 1 Plasma industry history at a glance A. Aghaie aghaie.a@gmail.com Abstract Background and Objectives The plasma industry started during World War II with the need for Plasma Derived Medicinal Products (PDMP). About 30 major plasma products are now commercially available, the most important of which are albumin, coagulation factors and immunoglobulin. Demand for these products is still growing, and these products have become particularly important not only in the treatment of diseases but also in global trade. The article is a brief overview on the evolution of plasma industry over the past eighty years. Materials and Methods This review was done by searching for articles in Google Scholar, PubMed, Scopus databases, based on aspects of the evolution of the plasma industry, and the cost of producing plasma derivatives, from the beginning of this industry, from 1940 to 2021. Additionally, private sector entry and cost and benefit of viral deactivation processes in plasma industry was selected. Results The plasma industry has experienced tremendous progress over the years and faced many problems, and despite advances in biotechnology, this industry is a unique necessity in the health of human societies. The production of plasma-derived pharmaceutical products is a complex activity and involves several stages of operational units. Conclusions  There are many challenges and opportunities in the future of plasma industry. It seems that the emergence of new pathogens, the need for new PDMPs, and the potential to create new consumer markets, will be a challenge for plasma industry in the future. But the increasing demand can provide a good opportunity to change strategies and optimize consumption. The development of recombinant methods provides a good alternative to these products. In addition, the potential of using surplus plasma for local production provides an opportunity for developing countries.   Plasma Industry Albumin 2022 3 01 61 74 http://bloodjournal.ir/article-1-1410-en.pdf
79-1439 2024-03-29 10.1002
Scientific Journal of Iran Blood Transfus Organ Sci J Iran Blood Transfus Organ 1027-9520 1735-8248 2022 19 1 SARS-COV-2 Virus; Immune Responses and The Immunopathogenesis N. Kazemibabaahmadi M. Kheirandish m.kheirandisah@ibto.ir Abstract Background and Objectives Clinical features of SARS-COV-2 virus include fever, headache, cough, sore throat, and shortness of breath, and in severe forms it leads to disseminated intravascular coagulation, septic shock, and ultimately death. Excessive secretion of proinflammatory cytokines such as TNF-α, IL-6, and IL-1 leads to cytokine storms in this disease. The emergence of new variants of the SARS-CoV-2 virus, which occurs following a high mutation of the virus, increases its ability to escape the immune system and improve its transmission power. This process, in turn, can lead to ineffective vaccines against the virus. Due to the effect of the emerging viruses on the safety of blood and its products, in the first part of this article, the topic of virology, immune responses, and immunopathogenesis of this virus were discussed. The second part will discuss the viral-related issues of blood safety and its products. Materials and Methods In this review, keywords were searched in Science Direct, PubMed, Scopus databases and the sites of Nature, Science, Elsevier, Cell, BMJ, and Lancet journals, and finally 148 articles were used. Results In this article, in addition to a brief review of SARS-CoV-2 and its new variants from a virological point of view, its immunology and immunopathogenesis are also discussed. Conclusions  Due to the widespread SARS-CoV-2 virus and its unprecedented nature in causing the disease, it is essential to address it. However, based on the genomic nature of the virus, the high probability of various mutations and the emergence of new variants, accurate and comprehensive information on the virus abilities to escape the immune system and its pathogenic mechanisms is not yet available. There are many contradictions in these topics. However, the latest available and reliable scientific materials at the time of the preparation of this article have been tried to be reviewed.     SARS-CoV-2 Immune Response Respiratory System 2022 3 01 75 97 http://bloodjournal.ir/article-1-1439-en.pdf