fa ارتباط شاخص‌های گلبول قرمز با CRP و IL-6 در بیماران مبتلا به Covid-19 بستری در بیمارستان‌های همدان در سال های 1399 و 1400 هماتولوژي Hematology پژوهشي Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span style="font-weight:bold"><span lang="FA" style="line-height:80%"><span style="font-family:Jadid"><span style="font-weight:normal">چکید</span></span></span><span lang="AR-SA" style="line-height:80%"><span style="font-family:Jadid"><span style="font-weight:normal">ه</span></span></span><span lang="FA" style="line-height:80%"><span style="font-family:Jadid"><span style="font-weight:normal"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><i><span lang="FA" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:Titr">سابقه و هدف </span></span></span></i></b></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:">همه‌گیری کووید-19 ضمن ایجاد مشکلات بهداشتی- درمانی موجب مرگ و میر بیماران گردید. شناسایی فوری بیماران، بررسی پارامترهای ایمونولوژیک و هماتولوژیک و ارتباط آن‌ها با یکدیگر در تعیین روند درمان اهمیت دارد. لذا این پژوهش باهدف بررسی ارتباط شاخص‌های گلبول قرمز با </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">CRP</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> و </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">IL-6</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> در بیماران مبتلا به کووید-19 انجام ‌شده است.</span></span></span></b></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><i><span lang="FA" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:Titr">مواد و روش‌ها</span></span></span></i></b></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:">در این مطالعه مقطعی توصیفی- تحلیلی، اطلاعات 280 پرونده‌ مربوط به بیماران بستری مبتلا به کووید-19 بیمارستان‌های همدان در سال‌های 1399 و 1400 در نرم‌افزار </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">SPSS</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> نسخه 27 وارد گردید. داده‌ها با استفاده از آزمون مربع کای و ضریب همبستگی اسپیرمن و 05/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">p<</span></span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> تحلیل شد.</span></span></span></b></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><i><span lang="FA" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:Titr">یافته‌ها</span></span></span></i></b></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:">با بررسی پرونده افراد مبتلا به کرونا مشخص شد که شاخص‌های </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">Hb</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> ، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">Hct</span></span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> ، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">MCHC</span></span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> ، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">RDW</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> و </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">MCV</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> با ضریب همبستگی‌های 16/0 ، 19/0 ، 16/0، 21/0 و 23/0 با میزان </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">IL-6</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> ارتباط معناداری دارند (به ترتیب 007/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">p=</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> ، 002/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">p=</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> ، 009/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">p=</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> ، 001/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">p<</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> و 001/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">p<</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:">). این در حالی است که هیچ یک از شاخص‌های مورد بررسی با میزان </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span bold="" new="" roman="" style="font-family:" times="">CRP</span></span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:"> ارتباط معناداری ندارند.</span></span></span></b></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><i><span lang="FA" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:Titr">نتیجه گیری</span></span></span></i></b></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span 2="" lotus="" style="font-family:">ارزیابی دقیق شاخص‌های گلبول قرمز و ارتباط آن‌ها با پارامترهای ایمونولوژیک در انتخاب روش درمانی مناسب، پیش‌بینی شدت بیماری و تظاهرات بالینی، تعیین سطح خدمات مورد نیاز و تأمین مراقبت‌های ویژه برای بیماران کمک‌کننده است.</span></span></span></b></span></span></span></span></span></span></span><br> &nbsp;</div> <div dir="rtl" style="text-align: left;"><span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:12.0pt">Abstract</span></b><b><span style="font-size:12.0pt"></span></b></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><i>Background and Objectives</i></b></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times="">The covid-19 epidemic leads to more mortality while creating health-treatment problems. Exact identification of the patients, evaluation of immunologic and hematologic parameters and their relationship is important in determining the treatment process. Therefore, this study was conducted with the aim of investigating the relationship between red blood cell indices and CRP and IL-6 in patients with covid-19.</span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><i>Materials and Methods</i></b></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times="">In this descriptive-analytical cross-sectional study, the data of 280 hospitalized patients with covid-19 in 3 Hamedan hospitals during 2020 and 2021 were entered in SPSS version 27 software. Data were analyzed using Chi square test, Spearman correlation coefficient, with the significance level (p< 0.05).</span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><i>Results</i></b></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times="">By evaluation of the data of covid-19 patients, it was found that Hb, Hct, MCHC, RDW, and MCV indices with correlation coefficient of 0.16, 0.19, 0.16, 0.21, and 0.23 are related to IL-6 level significantly (p : 0.007, 0.002, 0.009, < 0.001, and < 0.001, respectively). Meanwhile, none of these indices have a significant relationship with the CRP level.</span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><i>Conclusions&nbsp; </i></b></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times="">Accurate assessment of red blood cell indices and their relationship with immunological parameters could be helpful in term of choosing proper treatment method, predicting disease severity and clinical manifestations, determining required service level, and providing intensive care for patients.</span></span></span></span></span><br> <br> <br> &nbsp;</div> کووید-19, گلبول‌های قرمز, شاخص‌های گلبول قرمز, CRP COVID-19, Red Blood Cells, Red Cell Indices, C-Reactive Protein 160 168 http://bloodjournal.ir/browse.php?a_code=A-10-1549-2&slc_lang=fa&sid=1 M. Mokariani مهدیس مکاریانی 9100319475328460024946 9100319475328460024946 No مرکز پژوهش دانشجویان دانشگاه علوم پزشکی همدان Z. Mokariani زهرا مکاریانی 9100319475328460024947 9100319475328460024947 No مرکز پژوهش دانشجویان دانشگاه علوم پزشکی همدان F. Amiri فاطمه امیری f.amiri@umsha.ac.ir 9100319475328460024948 9100319475328460024948 Yes Hamedan University of Medical Sciences استادیار دانشکده پیراپزشکی دانشگاه علوم پزشکی همدان F. Ghadamghahi فاطمه قدمگاهی 9100319475328460024949 9100319475328460024949 No دانشکده بهداشت دانشگاه علوم پزشکی تهران