Journal of Iranian Blood Transfusion
فصلنامه پژوهشی خون
bloodj
Medical Sciences
http://bloodjournal.ir
91
journal91
1027-9520
1735-8248
10.61882/bloodj
fa
jalali
1402
6
1
gregorian
2023
9
1
20
3
online
1
fulltext
fa
تغییرات شاخصهای خون در افراد مبتلا به کووید-19 بستری در بیمارستان بعثت همدان در سالهای 1399 و 1400
Evaluation of blood index changes in Covid-19 inpatients of Hamadan Besat hospital in 2020-2021
هماتولوژي
Hematology
پژوهشي
Research
<div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span style="font-weight:bold"><span lang="FA" style="line-height:80%"><span style="font-family:Jadid"><span style="font-weight:normal">چکید</span></span></span><span lang="AR-SA" style="line-height:80%"><span style="font-family:Jadid"><span style="font-weight:normal">ه</span></span></span><span lang="FA" style="line-height:80%"><span style="font-family:Jadid"><span style="font-weight:normal"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i><span lang="FA" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:Titr">سابقه و هدف </span></span></span></i></b></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">شاخصهای خون در بیماری کووید-19 تغییراتی دارند که میتوانند در تعیین سیر بیماری مؤثر باشند. در این مطالعه تغییرات شاخصهای خونی در افراد مبتلا به کووید-19 مورد بررسی قرار گرفت. </span></span></span></b></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i><span lang="FA" style="font-family:Titr">مواد و روشها</span></i></b></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">در این مطالعه توصیفی مقطعی، تغییرات پلاکت، گلبول سفید، گلبول قرمز، هموگلوبین، هماتوکریت، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">RDW</span></span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> ، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">MCV</span></span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> ، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">MCH</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> و </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">MCHC</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> روز اول و هفتم 167 بیمار مبتلا به کووید-19 بررسی شدند. تحلیل داده­ها با نرمافزار </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">SPSS</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> نسخه 26 صورت گرفت. جهت مقایسه کمی آزمون غیر پارامتری ویل­کاکسون و مقایسه کیفی ـ رتبه­ای از آزمون مونته کارلو استفاده شد. </span></span></span></b></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i><span lang="FA" style="font-family:Titr">یافتهها</span></i></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">میانگین شاخص­های خونی روز اول و هفتم، به ترتیب گلبول قرمز 59/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 64/4 و 62/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 39/4 میلیون در میکرولیتر (001/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">p<</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">)، گلبول سفید 84/3 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 20/6 و 13/4 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 55/7 هزار در میکرولیتر (001/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">p<</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">)، پلاکت 14/90 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 54/179 و 03/109 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 76/269 هزار در میکرولیتر (001/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">p<</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">)، هموگلوبین 71/1 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 20/13 گرم در دسیلیتر و 77/1 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 27/12 گرم در دسیلیتر (001/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">p<</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">)، هماتوکریت 67/4 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 45/40 و 02/5 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 16/38 درصد (001/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">p<</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">)، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">RDW</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 55/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 1/12 و 66/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 1/13 درصد (001/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">p<</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">)، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">MCV</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 43/5 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 18/87 و62/5 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 15/87 فمتولیتر، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">MCH</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 16/2 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 47/28 و 03/2 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 18/28 پیکوگرم (002/0 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">p=</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">) و </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">MCHC</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 63/1 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 56/32 و 64/1 </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%">±</span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> 35/32 گرم در دسیلیتر بود. </span></span></span></b></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i><span lang="FA" style="font-family:Titr">نتیجه گیری</span></i></b></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">میزان گلبول سفید، پلاکت و </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">RDW</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> نسبت به روز اول بستری افزایش و میزان گلبول قرمز، هماتوکریت، هموگلوبین، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">MCH</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> ، </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">MCV</span></span></span></b><b><span style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> و </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold"">MCHC</span></span></span></b><b><span lang="FA" style="font-size:11.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> نسبت به روز اول کاهش یافته بود. </span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:"Times New Roman Bold""></span></span></span></b></span></span></span></span></span></span><br>
</div>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:12.0pt">Abstract</span></b><b><span style="font-size:12.0pt"></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i>Background and Objectives</i></b></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif"">Blood indices have variation in Covid-19 that could affect diagnosis. Blood index changes in Covid-19 inpatiens were evaluated.</span></span></span></span></span><br>
<br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i>Materials and Methods</i></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif"">In a descriptive/cross-sectional study, 167 Covid-19 inpatients in Besat Hospital in Hamedan were selected and in terms of changes on the first and seventh days of the blood indices were investigated. Data analysis was done with SPSS software version 26. In order to compare the blood indices on the first and seventh days of hospitalization, Wilcoxon and Monte Carlo tests were used.<span lang="AR-SA" dir="RTL" style="font-family:"Traditional Arabic""></span></span></span></span></span></span><br>
<br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i>Results</i></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif"">The average blood indices on the first and seventh day were 4.64 ± 0.59 and 4.39 ± 0.62 million in microliter (p< 0.001) for RBCs, 6.20 ± 3.84 and 7.55± 4.13 thousand in microliter (p< 0.001) for white blood cells, 179.54 ± 90.14 and 269.76 ± 109.03 thousand in microliter (p< 0.001) for platelets, 13.20 ± 1.71 and 12.27 ± 1.77 g/dL (p< 0.001) for hemoglobin, 40.45 ± 4.67 and 38.16 ± 5.02 % (p< 0.001) for hematocrit, 12.5 ± 0.55 and 13.1 ± 0.66 % (p< 0.001) for RDW, 87.18 ± 5.43 and 87.15 ± 5.62 femtoliters for MCV, 28.47 ± 2.16 and 28.18 ± 2.03 picograms (p= 0.002) for MCH and 32.56 ± 1.63 and 32.35 ± 1.64 g/dL for MCHC.</span></span></span></span></span><br>
<br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i>Conclusions </i></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif"">Blood indices in Covid-19 inpatients undergo changes from the time of admission to the seventh day. White blood cell, platelet and RDW were increased and red blood cell, hematocrit, hemoglobin, MCV, MCH and MCHC decreased compared to the first day of hospitalization.</span></span></span></span></span><br>
<br>
کلمات کلیدی: شمارش پلاکت, شمارش گلبول سفید, اندکسهای گلبول قرمز
Key words: Platelet Count, White Blood Cell Count, Red blood cell indices
204
213
http://bloodjournal.ir/browse.php?a_code=A-10-818-4&slc_lang=fa&sid=1
F.
Amiri
فاطمه
امیری
amirif2012@gmail.com
9100319475328460024274
9100319475328460024274
Yes
استادیار گروه علوم آزمایشگاهی دانشکده پیراپزشکی دانشگاه علوم پزشکی همدان
E.
Solgi
الهام
سلگی
9100319475328460024275
9100319475328460024275
No
دانشکده پزشکی دانشگاه علوم پزشکی همدان
N.
Mohammadi parsa
نرگس
محمدی پارسا
9100319475328460024276
9100319475328460024276
No
دانشکده پزشکی دانشگاه علوم پزشکی همدان
H.
Rafeemehr
حسن
رفیعی مهر
9100319475328460024277
9100319475328460024277
No
دانشیار گروه علوم آزمایشگاهی دانشکده پیراپزشکی دانشگاه علوم پزشکی همدان