Journal of Iranian Blood Transfusion
فصلنامه پژوهشی خون
bloodj
Medical Sciences
http://bloodjournal.ir
91
journal91
1027-9520
1735-8248
10.66224/bloodj
fa
jalali
1402
4
1
gregorian
2023
7
1
20
2
online
1
fulltext
fa
تأثیر CRP، LDH و IL-6 بر شدت بیماری در بیماران مبتلا به ویروس کرونا در بیمارستان سینا، سال 1399
Evaluation of the effect of IL-6, LDH, CRP levels on the disease severity in patients with coronavirus in Sina Hospital in 2020
ايمونولوژي
Imunology
پژوهشي
Research
<div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span style="font-weight:bold"><span lang="FA" style="line-height:80%"><span style="font-family:Jadid"><span style="font-weight:normal">چکید</span></span></span><span lang="AR-SA" style="line-height:80%"><span style="font-family:Jadid"><span style="font-weight:normal">ه</span></span></span><span lang="FA" style="line-height:80%"><span style="font-family:Jadid"><span style="font-weight:normal"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i><span lang="FA" style="font-size:9.0pt"><span style="line-height:80%"><span style="font-family:Titr">سابقه و هدف </span></span></span></i></b></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">کرونا بیماری است که به سرعت گسترش یافته، باعث صدمات جبرانناپذیر و مرگ میشود. جهت پیشبینی و توسعه الگوریتمهای درمانی، بررسی نشانگرهای زیستی در تعیین شدت بیماری در افراد مبتلا اهمیت دارد. لذا این پژوهش با هدف بررسی ارتباط اینترلوکین-6، پروتئین واکنشگر </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Romans","serif"">C</span></span></b><b><span style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> و لاکتات دهیدوژناز با شدت بیماری </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Romans","serif"">COVID-19</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> در بیماران مبتلا به ویروس کرونا انجام شده است.</span></span></span></b></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i><span lang="FA" style="font-family:Titr">مواد و روشها</span></i></b></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">در</span></span></span></b><b> </b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">این مطالعه مقطعی، توصیفی ـ تحلیلی، اطلاعات پروندههای 365 بیمار بستری مبتلا به کرونا در بیمارستان سینا همدان طی سال 99 که به صورت تصادفی انتخاب شدند، در نرمافزار </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">SPSS</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> نسخه 26 وارد گردید. شدت بیماری در بیماران طبق منبع مورد نظر و علائم بالینی اندازهگیری شد و به دو سطح دستهبندی گردید. اطلاعات با استفاده از آزمون ناپایداری همبستگی گاما، ضریب تأثیر </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">d</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> سومر و سطح معناداری 05/0></span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">p</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> تحلیل شد.</span></span></span></b></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i><span lang="FA" style="font-family:Titr">یافتهها</span></i></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">با بررسی پرونده افراد مبتلا به کرونا مشخص شد که </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">IL-6</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> با ضریب همبستگی 506/0، </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">LDH</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> با ضریب همبستگی 291/0 و </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">CRP</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> با ضریب همبستگی 23/0، همه در سطح 01/0 بر شدت بیماری کرونا تأثیر مثبت دارند که میزان این تأثیر مثبت بر اساس ضریب تأثیر </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">d</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> سومر به ترتیب 839/0، 458/0 و 358/0 بود(01/0 </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">p=</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">).</span></span></span></b></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i><span lang="FA" style="font-family:Titr">نتیجه گیری</span></i></b></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:80%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">بیماران مبتلا به </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">COVID-19</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> شدید به طور قابل توجهی سطوح سرمی </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">CRP</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">، </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">LDH</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> و </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">IL-6</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> بالاتری دارند. سطح پایه </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">IL-6</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus"">، </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">CRP</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> و </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">LDH</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> ارتباط نزدیکی با شدت </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">COVID-19</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> دارد. این نشانگرهای آزمایشگاهی میتوانند به عنوان شاخصهای بالینی و پیشآگهی </span></span></span></b><b><span dir="LTR" style="line-height:80%"><span style="font-family:"Times New Roman Bold","serif"">COVID-19</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:80%"><span style="font-family:"2 Lotus""> استفاده شوند.</span></span></span></b></span></span></span></span></span></span></div>
<div dir="rtl" style="text-align: left;"><span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:12.0pt">Abstract</span></b><b><span style="font-size:12.0pt"></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i>Background and Objectives</i></b></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif"">Corona is caused by a viral infection called acute respiratory syndrome corona virus 2 which spreads rapidly, causing irreparable damage and death. In order to predict and develop treatment algorithms, the study of biomarkers is important in determining the severity of the disease. Therefore, we investigated the correlation of Interleukin 6 IL-6, Lactate dehydrogenase LDH, C reactive protein CRP and disease severity in COVID-19 patients.</span></span></span></span></span><br>
<br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i>Materials and Methods</i></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif"">In this descriptive and analytical cross-sectional study, the information of 365 coronavirus hospitalized patients randomly selected in Sina Hamadan hospital during 2019 was entered into SPSS 26. The severity of the disease was also measured according to the defined reference and clinical symptoms and classified into two levels. The data were analyzed with gamma correlation instability test, Somers' D at significance level of p value <0.05.</span></span></span></span></span><br>
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<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i>Results</i></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif"">It was found that IL-6 with a correlation coefficient of 0.506, LDH with a correlation coefficient of 0.291 and CRP with a correlation coefficient of 0.23, all at the level of 0.01 (p value = 0.01), have a positive effect on the severity of Corona disease and the amount of this positive effect is based on Somers' effect coefficient d 0.839, 0.458 and 0.358, respectively.</span></span></span></span></span><br>
<br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><i>Conclusions </i></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif"">Patients with severe COVID-19 have significantly higher serum levels of CRP, LDH and IL-6. Baseline levels of IL-6, CRP, and LDH were closely related to the severity of COVID-19 disease. These laboratory markers can be used as clinical indicators of disease exacerbation and prognosis of COVID-19.</span></span></span></span></span><br>
<br>
</div>
کلمات کلیدی: ویروس, IL-6 , شدت بیماری
Key words: Virus, IL-6, Disease Severity
134
142
http://bloodjournal.ir/browse.php?a_code=A-10-1549-1&slc_lang=fa&sid=1
Z.
Mokariani
زهرا
مکاریانی
9100319475328460024135
9100319475328460024135
No
مرکز پژوهش دانشجویان دانشگاه علوم پزشکی همدان
M.
Mokariani
مهدیس
مکاریانی
9100319475328460024136
9100319475328460024136
No
مرکز پژوهش دانشگاه علوم پزشکی همدان
F.
Amiri
فاطمه
امیری
Amirif2012@gmail.com
9100319475328460024137
9100319475328460024137
Yes
استادیار گروه علوم آزمایشگاهی، دانشکده پیراپزشکی دانشگاه علوم پزشکی همدان