TY - JOUR T1 - L-Asparginase effect with 6000U/m2 on lipid profile in children with acute lymphoblastic leukemia TT - اثر داروی ال آسپارژیناز با دوز 6000 واحد بر متر مربع بر سطح چربی‌های خون در کودکان مبتلا به لوکمی لنفوبلاستیک حاد JF - Blood-Journal JO - Blood-Journal VL - 6 IS - 2 UR - http://bloodjournal.ir/article-1-319-en.html Y1 - 2009 SP - 85 EP - 93 KW - Leukemia KW - Lymphoblastic KW - Acute KW - L-Asparagine KW - children N2 -   Abstract  Background and objectives One of the major etiologies of lipid disorders in malignancies is the use of chemotherapy drugs, the most important of which is L-Asparginase. Studies in different centers with high dosages of L-Asparginase demonstrated different results. The aim of this study is to evaluate the effect of L-Asparginase at a dose of 6000 U/m2 on lipid profile in Iranian children with newly diagnosed acute lymphoblastic leukemia in Mofid Children Hospital of Tehran .    Materials and Methods We performed a nonrandomized trial in which all children with newly diagnosed acute lymphoblastic leukemia (ALL) aged M3 ER -