TY - JOUR JF - Blood-Journal JO - Sci J Iran Blood Transfus Organ VL - 18 IS - 3 PY - 2021 Y1 - 2021/10/01 TI - Association of rs855791TMPRSS6 polymorphism with iron deficiency anemia TT - ارتباط پلی‌مورفیسم rs855791 TMPRSS6 با آنمی فقر آهن N2 - Abstract Background and Objectives According to the relevant studies, among the reported TMPRSS6 polymorphisms associated with iron deficiency anemia, rs855791 has the highest association with hemoglobin level and disease severity. The aim of this study was to investigate the relationship between rs855791and iron deficiency anemia in Sanandaj. Materials and Methods In this case-control study conducted in the Spring of 2016, the frequency of rs855791 polymorphism in TMPRSS6 gene was evaluated in 40 patients with iron deficiency anemia and 80 healthy randomly selected individuals without age and sex restrictions by PCR-RFLP method. Then, the relationship between rs855791 and the level of hemoglobin, ferritin, and MCV in sick and healthy individuals was investigated by SPSS V19 statistical software. Results The frequencies of CC, CT, and TT among 40 patients were 15, 37.5, and 47.5 and they were 33.75, 42.5, and 23.75% among 80 healthy controls, respectively. Therefore, there was a significant relationship between TT genotype and disease (p= 0.010). Also, a significant relationship was observed between the frequency of CC and the absence of disease [OR= 0.34, p= 0.035]. The higher frequency of CT in the control group than the indicates a lower risk of people with CT genotype. The results also show a significant relationship between low Hb, MCV, and Ferritin with the genotype so that people with TT genotype had lower Hb, MCV, and ferritin than people with CC and TC genotypes. Conclusions TMPRSS6 rs855791 polymorphism was shown to be effective in subject patients with iron deficiency anemia in Sanandaj city. SP - 205 EP - 214 AU - Baban, َA. AU - Keshavarzi, F. AU - Nikkhoo, B. AD - KW - Iron-Deficiency Anemia KW - Ferritin KW - Hemoglobin UR - http://bloodjournal.ir/article-1-1405-en.html ER -