TY - JOUR JF - Blood-Journal JO - Sci J Iran Blood Transfus Organ VL - 18 IS - 3 PY - 2021 Y1 - 2021/10/01 TI - Evaluation of alloantibodies in thalassemia patients referred to Hamadan Besat hospital in 2019 TT - میزان آنتی‌بادی‌های ناخواسته در بیماران تالاسمی مراجعه‌کننده به بیمارستان بعثت همدان در سال 1398 N2 - Abstract Background and Objectives Chronic blood transfusion can cause alloimmunization in patients with thalassemia. Estimating the frequency of alloimmunization in thalassemia patients can lead to the recognition of existing limitations and the development of appropriate strategies to prevent alloimmunization in thalassemia patients. In this study, we evaluated the prevalence of alloimmunization among patients of thalassemia. Materials and Methods In this cross-sectional and retrospective study, the study population was 92 patients with thalassemia referred to Besat Hospital in Hamadan in 2019. The data of all thalassemia patients was collected by census method and entered into SPSS software version 16. The Data was analyzed using Logestic Regression and significance level by p < 0.05. Results 92 patients including 54 male (58.7% ) and 38 female (41.3%), aged 2-50 years were studied. Among 92 patients, 7 people (7.6%) had positive antibody screening results. The most prevalent detected alloantibodies were anti-c with 6 patients (33.3%), anti-e with 3 patients (16.6%) and anti-JKa with 3 patients (16.6%). The meaningful relation was observed between alloimmunization and hemoglobin concentration (p = 0.006), and alloimmunization and number of blood transfusion (p= 0.009). But there was no significant relation between alloimmunization and age. Conclusions According to the results of this study, anti-c, anti-e, and anti-JKa are the most prevalent alloantibodies in the thalassemia patients in Hamadan. This point could be useful to provide suitable matched blood units for thalassemia patients. SP - 187 EP - 195 AU - Afshari, M. AU - Amiri, F. AU - Seyedi, M.R. AU - Biglari, M. AU - Jambozorg, H. AD - KW - Thalassemia KW - Blood Transfusion KW - Screening UR - http://bloodjournal.ir/article-1-1400-en.html ER -