TY - JOUR T1 - Determination of HBs Ab stability after HBV vaccination in multitransfused patients, Hajar Hospital, Shahrekord, 2003 TT - ارزیابی دوام HBsAb بعد از واکسیناسیون در دریافت‌کنندگان مکرر خون و فرآورده‌های خونی بیمارستان هاجر شهر کرد، سال 1381 JF - Blood-Journal JO - Blood-Journal VL - 3 IS - 3 UR - http://bloodjournal.ir/article-1-106-en.html Y1 - 2006 SP - 259 EP - 263 KW - Array KW - Hemophilia KW - Thalassemia KW - Vaccination KW - Transfusion N2 -   Abstract  Background and Objectives Hepatitis B virus (HBV) is one of the main causes of hepatitis, cirrhosis and hepatocellular carcinoma, and vaccination by anti-HBs is the only reliable method for its prevention. Since blood transfusion is one of the most important transmission routes of this virus, blood recipients may always be at its exposure. Considering the importance of vaccination in multitransfused patients, we decided to evaluate HBsAb level in them.   Materials and Methods In this cross sectional study with simple sampling, 83 patients with major thalassemia, 5 with hemophilia, and 5 with fanconi anemia, having been referred to Hajar Hospital of Shahrekord to receive blood and blood products in the year 2003 were evaluated for their level of HBsAb. The level of HBsAb was measured with Diasorin kit (sensitivity=95%, specificity=98%). Data were statistically analyzed with chi-square test.    Results Thirty patients (28.5%) were nonimmune, 11 (12.5%) were partially immune, and 52 (59%) were immune. Eighty eight patients had previous history of hepatitis B vaccination. Out of those who had received the last vaccination within the last 5 years, 82% were immune (p M3 ER -