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Frequency of Kell antigen in donor blood bags used in Adult Thalassemia Center
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A. Azarkeivan   , M. Hadavand Khani , M. Moghadam , Z. Shabeh pour , S. Alizadeh , M. Zareie |
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| Keywords: Key words: Thalassemia, Blood Donors, frequency |
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Type of Study: Research |
Subject:
Hematology
Published: 2016/01/4
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Full-Text: (8369 Views) |
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Sci J Iran Blood Transfus Organ 2016; 12(4): 303-310
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Frequency of Kell antigen in donor blood bags
used in Adult Thalassemia Center
Azarkeivan A.1,2, Hadavand Khani M.1,2, Moghadam M.1, Shabehpour Z.1,2,
Alizadeh S.1,2, Zareie M. 1,2
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Adult Thalassemia Clinic, Tehran, Iran
Abstract
Background and Objectives
Alloimmunization is one of the side effects of regular blood transfusion in thalassemic patients. We studied the frequency of Kell antigen in donor blood bags used in Adult Thalassemia Clinic in Tehran.
Materials and Methods
Our aim was to screen Kell antigen on the blood bags which came for use in Adult Thalassemia Clinic. First, we recorded the bag number with which we could access the characteristics of the blood donors such as sex, age, number of donation, and so on. Then, for Kell study, we used anti Kell kit on each cord detached from the blood bags. The results were collected and analysed by SPSS18.
Results
In our one year cross sectional study, we checked Kell antigen for 11557 blood bags; 98.7% were for male and 1.3% for female. The minimum age of our donors was 17 years old and maximium 65. Out of the total number of blood donors, 19.6 % were first time, 27.4% had the history of prior donation, and 52.9% were repeated donors. In our kell study for K or KEL1 antigen, we had 96.2% Kell negative bags and 3.8% were Kell positive.
Conclusions
We had the rate of less than 4% positivity of Kell antigen on our donors showing more than 96% Kell negativity. However, for the reduction of the risk of alloimmunization in chronically transfused patients, it is better to check all bags for Kell antigen and prevent the use of Kell positive bags.
Key words: Thalassemia, Blood Donors, frequency
Received: 21 Jan 2015
Accepted: 9 Sep 2015
Correspondence: Azarkeivan A., MD. Pediatrics Hematologist-Oncologist. Associate Professor of Research Center of Iranian Blood Transfusion Organization.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88074135; Fax: (+9821) 22087853
E-mail: azazarkeivan@yahoo.com
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Azarkeivan A, Hadavand Khani M, Moghadam M, Shabeh pour Z, Alizadeh S, Zareie M. Frequency of Kell antigen in donor blood bags used in Adult Thalassemia Center. Sci J Iran Blood Transfus Organ 2016; 12 (4) :303-310 URL: http://bloodjournal.ir/article-1-933-en.html
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