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:: Volume 12, Issue 2 (Summer 2015) ::
Sci J Iran Blood Transfus Organ 2015, 12(2): 183-205 Back to browse issues page
Umbilical cord blood: stem cells and ex vivo expansion methods
F. Mohammadali , A. Atashi , M. Soleimani , S. Abroun , A.A. Pourfathollah , S. Kaviani , M. Ajami , M. Ajami
Keywords: Key words : Umbilical Cord Blood, Stem Cells, Cord Blood Stem Cell Transplantation
Full-Text [PDF 548 kb]   (4383 Downloads)     |   Abstract (HTML)  (10282 Views)
Type of Study: Review Article | Subject: Stem cells
Published: 2015/07/5
Full-Text:   (12165 Views)
References :  
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Sci J Iran Blood Transfus Organ 2015; 12(2): 183-205
 
Review Article
 
 
 
 
 


Umbilical cord blood: stem cells and ex vivo
expansion methods
 
Mohammadali F.1, Atashi A.1, Soleimani M.1, Abroun S.1, Pourfathollah A.A.2,3,
Kaviani S.1, Ajami M.1, Ajami M.1
 
1Department of Hematology and Blood Banking, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
 
Abstract
Background and Objectives
Umbilical cord blood (UCB) is an accessible source of hematopoietic stem cells (HSCs). Along with the advantages, UCB also has limitations: the  low volume and  the absolute number of HSCs available in UCB leading to the delayed engraftment. Given the limitations, many investigators have sought to accelerate engraftment and increase the absolute number of stem cells in UCB units.
 
Materials and Methods
In the present study more than 200  published articles about UCB  were reviewed. This review article is aimed to focus on the importance of  using cord blood, the nature of stem cells in cord blood, and the ex vivo expansion techniques of  UCB HSC.
 
Results
UCB HSCs possess higher proliferative potentials and contain a higher proportion of primitive compartment as compared to bone marrow and  peripheral blood. Several studies have reported the presence of different cell populations besides HSCs in cord blood that enable the use of  these sources in immunotherapy, tissue engineering, and regenerative medicine. Thus, the strategies to isolate and expand selected subpopulations from UCB and the use of these cells  in treatment  of various diseases are the areas of active research.
 
Conclusions
Umbilical cord blood is an attractive source in both research and  modern clinical applications providinh a potentially useful alternative for patients who do not have an HLA-matched bone marrow donor. Besides the safety and feasibility of UCB, the other areas including the acceleration of the engraftment, the extension of access, the quality assurance, and the outcomes in the specific subgroups of patients are also required to be investigated.
 
Key words: Umbilical Cord Blood, Stem Cells, Cord Blood Stem Cell Transplantation
 
Received:  24 Jun 2014
Accepted: 15 Fec 2015
 
 

 

Correspondence: Soleimani M., PhD of Hematology and Blood Bank. Associate Professor of Faculty of Medical Sciences, Tarbiat Modares University.
P.O.Box: 14115-111, Tehran, Iran. Tel: (+9821) 88011001; Fax: (+9821) 88013030
E-mail: soleim_m@modares.ac.ir
Correspondence: Pourfathollah AA., PhD of Immunology. Professor of Faculty of Medical Sciences, Tarbiat Modares University and Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box:14115-111, Tehran, Iran. Tel: (+9821) 8801101; Fax: (+9821) 88013030
E-mail: pourfa@modares.ac.ir
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Mohammadali F, Atashi A, Soleimani M, Abroun S, Pourfathollah A, Kaviani S, et al . Umbilical cord blood: stem cells and ex vivo expansion methods. Sci J Iran Blood Transfus Organ 2015; 12 (2) :183-205
URL: http://bloodjournal.ir/article-1-874-en.html
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Volume 12, Issue 2 (Summer 2015) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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