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:: Volume 12, Issue 2 (Summer 2015) ::
Sci J Iran Blood Transfus Organ 2015, 12(2): 173-178 Back to browse issues page
The Prevalence of Yersinia Yop-specific IgA antibodies in Iranian blood donors evaluated by specific serology and blood culture methods
H. Timori Naghadeh , A. Dabir Moghaddam , Z. Pirmohammad Jamaat , R. Sharifi
Keywords: Key words : Yersinia enterocolitica, Septicemia, Blood Donors
Full-Text [PDF 222 kb]   (1398 Downloads)     |   Abstract (HTML)  (5387 Views)
Type of Study: Research | Subject: Blood Transfusion
Published: 2015/07/5
Full-Text:   (1362 Views)
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Sci J Iran Blood Transfus Organ 2015; 12(2): 173-178
 
Original  Article
 
 

The Prevalence of Yersinia Yop-specific IgA antibodies
in Iranian blood donors evaluated by specific serology
and blood culture methods
 
Timori Naghadeh H.1, Dabir Moghaddam A.1 , Pirmohammad Jamaat Z.1, Sharifi R.1,2
 
 
 
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Tehran Regional Educational Blood Transfusion Center, Tehran, Iran
 
Abstract
Background and Objectives
The recomwell Yesinia uses YOPs (Yesinia outer membrane proteins) produced by recombinant techniques that are highly specific for the genus Yersinia. The aim of this study is to determine the prevalence of Yesinia Yop-specific IgA antibodies in 492 healthy blood donors and make comparison between seropositivity and the presence of y.enterocolitica infection in blood donors.
 
Materials and Methods
In the descriptive study, sera from 492 healthy Iranian blood donors were studied for Yesinia Yop-specific IgA antibodies by two different techniques, enzyme immunoassay (EIA) and western blot to determine the prevalence of Yersinia antibody. Secondly, we cultured the whole blood of Yesinia seropositive donors which has been stored in 1-6 C for 35 days. Thirdly, we compared  the rate of seropositivity with the results of donors’ blood cultures.
 
Results
The prevalence rates of Yesinia Yop-specific IgA antibodies in Tehran healthy blood donors were 12.5% and 8.5% by EIA and Western Blot, respectively. The blood cultures of all seropositive donors were negative. 
 
Conclusions
Although the prevalence rate of Yesinia Yop-specific IgA antibodies in Iranian healthy blood donors was high there was no correlation whatsoever between seropositivity and donors’ bacteremia.
 
Key words: Yersinia enterocolitica, Septicemia, Blood Donors
 
 
 
 
 
 
 
Received:  28 May 2014
Accepted: 28 Fec  2015
 
 

 

Correspondence: Timori Naghadeh H., Pathologist. Assistant Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 1157-14665, Tehran, Iran. Tel: (+9821) 88601564; Fax: (+9821) 88060717
E-mail: timori13@gmail.com
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Timori Naghadeh H, Dabir Moghaddam A, Pirmohammad Jamaat Z, Sharifi R. The Prevalence of Yersinia Yop-specific IgA antibodies in Iranian blood donors evaluated by specific serology and blood culture methods. Sci J Iran Blood Transfus Organ 2015; 12 (2) :173-178
URL: http://bloodjournal.ir/article-1-867-en.html


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Volume 12, Issue 2 (Summer 2015) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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