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1University of Isfahan,Isfahan, Iran 2School of Science, University of Isfahan,Isfahan, Iran 3Department of Cellular Biotechnology at Cell Science Research Center, ACECR, Royan Institute for Biotechnology, Isfahan, Iran 4Isfahan University of Medical Sciences, Isfahan, Iran 5Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 6Cellular & Molecular Immunology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract Background and Objectives
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease in which the body’s natural defense system attacks myelin on neuronal cells. One of the most important immune system cells involved in MS is Th17 which is one of the main cells involved in most of autoimmune diseases. Recently, microRNAs (miRNAs) have been remarkably used in treating many kinds of diseases. MicroRNAs are endogenous 22-25 nt RNAs playing an important regulatory roles in cellular and developmental processes.
Materials and Methods
The goal of this article is to determine miRNAs which possibly have the most effect in the pathway of differentiation to Th17 cells by using miRWalk database and candidate microRNAs that can suppress this pathway and limit the disease’s symptoms. Our in-silico studies identified the possible role of several miRNAs in differentiation of naïve CD4+ cells to Th17 cells.
Results
miR-93,miR-20a/b are probably applicable to inhibit the differentiation of naïve T cells into Th17 cells to reduce the progress of MS and also to be used as markers of diagnosis of MS in early stages.
Conclusions
According to our results miR-20a/b&miR-93 can possibly be the key miRNAs, inhibiting the progression of MS by preventing the differentiation to Th17 cells.
Correspondence: Ghaedi K, PhD of Molecular Biology. Associate Professor of School of Science , Isfahan University of Medical Sciences & Department of Cellular Biotechnology at Cell Science Research Center, ACECR, Royan Institute for Biotechnology.
Postal code: 81746-73441, Isfahan, Iran. Tel: (+98311) 7932479 ; Fax: (+98311) 7932456
E-mail: kamranghaedi@yahoo.com
Naghavian R, Honardoost M, Hosseini A, Ghaedi K, Etemadifar M, Nasr Esfahani M et al . The possibility of miR-20a/b & miR-93 role in differentiation of naïve CD4+ to Th17 cells in multiple sclerosis. Sci J Iran Blood Transfus Organ 2015; 12 (1) :39-45 URL: http://bloodjournal.ir/article-1-845-en.html