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:: Volume 10, Issue 3 (Autumn 2013) ::
Sci J Iran Blood Transfus Organ 2013, 10(3): 267-281 Back to browse issues page
Comparison of Human Leukocyte Antigen Frequency in Iranian unrelated Stem cell donors during 2011-2012
M. Shaiegan , H. Abolghasemi , F. Yari , M. Paridar , M. Maghsudlu , S. Amini Kafiabad , Sh. Kashani , A, Heydari , A. Gharehbaghian , F. Sabaghi , M. Sobhani , M. Amani , M Taheri , M. Paknejad
Keywords: HLA-A, HLA-B, HLA DRB1, Allele Frequency, Iran
Full-Text [PDF 441 kb]   (2211 Downloads)     |   Abstract (HTML)  (9506 Views)
Type of Study: Research | Subject: Stem cells
Published: 2013/10/7
Full-Text:   (1717 Views)
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Original Article
 
 
 
 
Sci J Iran Blood Transfus Organ 2013; 10(3): 267-281
 
 
 

Comparison of Human Leukocyte Antigen Frequency
in Iranian unrelated Stem cell donors during 2011-2012
 
Shaiegan M.1, Abolghasemi H.2, Yari F.1, Paridar M.1, Maghsudlu M.1, Amini Kafiabad S.1,
Kashani Sh.1,3, Heidari A.1, Gharehbaghian A.2,4, Sabbaghi F.1, Sobhani M.1,5, Amani M.1,
Taheri M.1, Paknejad M.1
 
 
 
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Tehran Regional Educational Blood Transfusion Center, Tehran, Iran
4Pediatric Congenital Hematologic Disorders Research Center of Shahid Beheshti University of Medical Sciences,
Tehran, Iran
5Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
 
 
 
Abstract
Background and Objectives
The distribution of HLA alleles varies among different ethnic populations. Obtaining HLA data for different ethnic groups will be helpful to determine donor recruitment goals and strategies in unrelated stem cell registries.
 
Materials and Methods
Based on the data available from the Iranian Stem Cell Donor Registry, the frequency rates of HLA-A, B, DRB1 alleles evaluated by PCR-SSP method were reported; 1513 individuals living in Tehran city with six different ethnicities (Fars, Azeri, Kurd, Lur, Gilak, and Mazani) were the participants. 
 
Results
Out of 1513 participants, Fars and Azeri ethnic groups had the highest number with 63.12% and 20.02%, respectively. Twenty one HLA-A, thirty-one  HLA-B, and  thirteen  HLA-DRB1 alleles were observed. Data analysis among different ethnicities showed no significant differences between Fars and Azeries except for HLA-DRB1*33 frequency (p< 0.005). Significant differences between Fars and Kurds were seen in HLA-A*03/11 and HLA-B*08/51 frequencies. There were significant differences between Fars and Gilaks in HLA-A*03/26, HLA-B*38/52 frequencies (p< 0.05).   
 
Conclusions 
The number of reported alleles in this study was similar to previous ones. There is not much alleles diversity, despite a few differences, across the different ethnic groups. 
 
Key words: HLA-A, HLA-B, HLA DRB1, Allele Frequency, Iran
 
Received: 14 Nov 2012
Accepted:  8 Apr  2013
 
 
 

Correspondence: Shaiegan M., PhD of Immunology. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88601564; Fax: (+9821) 88601599
E-mail:
M.Shaiegan@ibto.ir
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Shaiegan M, Abolghasemi H, Yari F, Paridar M, Maghsudlu M, Amini Kafiabad S, et al . Comparison of Human Leukocyte Antigen Frequency in Iranian unrelated Stem cell donors during 2011-2012. Sci J Iran Blood Transfus Organ 2013; 10 (3) :267-281
URL: http://bloodjournal.ir/article-1-796-en.html


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Volume 10, Issue 3 (Autumn 2013) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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