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1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran 2Shahid Beheshti University of Medical Sciences, Tehran, Iran 3Tehran Regional Educational Blood Transfusion Center, Tehran, Iran 4Pediatric Congenital Hematologic Disorders Research Center of Shahid Beheshti University of Medical Sciences, Tehran, Iran 5Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
Abstract Background and Objectives
The distribution of HLA alleles varies among different ethnic populations. Obtaining HLA data for different ethnic groups will be helpful to determine donor recruitment goals and strategies in unrelated stem cell registries.
Materials and Methods
Based on the data available from the Iranian Stem Cell Donor Registry, the frequency rates of HLA-A, B, DRB1 alleles evaluated by PCR-SSP method were reported; 1513 individuals living in Tehran city with six different ethnicities (Fars, Azeri, Kurd, Lur, Gilak, and Mazani) were the participants.
Results
Out of 1513 participants, Fars and Azeri ethnic groups had the highest number with 63.12% and 20.02%, respectively. Twenty one HLA-A, thirty-one HLA-B, and thirteen HLA-DRB1 alleles were observed. Data analysis among different ethnicities showed no significant differences between Fars and Azeries except for HLA-DRB1*33 frequency (p< 0.005). Significant differences between Fars and Kurds were seen in HLA-A*03/11 and HLA-B*08/51 frequencies. There were significant differences between Fars and Gilaks in HLA-A*03/26, HLA-B*38/52 frequencies (p< 0.05).
Conclusions
The number of reported alleles in this study was similar to previous ones. There is not much alleles diversity, despite a few differences, across the different ethnic groups.
Correspondence: Shaiegan M., PhD of Immunology. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88601564; Fax: (+9821) 88601599
E-mail: M.Shaiegan@ibto.ir
Shaiegan M, Abolghasemi H, Yari F, Paridar M, Maghsudlu M, Amini Kafiabad S, et al . Comparison of Human Leukocyte Antigen Frequency in Iranian unrelated Stem cell donors during 2011-2012. Sci J Iran Blood Transfus Organ 2013; 10 (3) :267-281 URL: http://bloodjournal.ir/article-1-796-en.html